Serum Leptin and Ghrelin Levels in Women with Polycystic Ovary Syndrome: Correlation with Anthropometric, Metabolic, and Endocrine Parameters
Background Polycystic ovary syndrome (PCOS) patients are more prone to abnormal production of some regulatory peptides. In these patients, studies on the serum levels of leptin and ghrelin are controversial. This study aims to investigate serum levels of leptin and ghrelin and their correlation...
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Royan Institute (ACECR), Tehran
2012-07-01
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| Series: | International Journal of Fertility and Sterility |
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| Online Access: | http://www.ijfs.ir/article_45133_06de73ba25b293e0f8ce85295acf392a.pdf |
| _version_ | 1819171819587895296 |
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| author | Shiva Houjeghani Bahram Pourghassem Gargari Laya Farzadi |
| author_facet | Shiva Houjeghani Bahram Pourghassem Gargari Laya Farzadi |
| author_sort | Shiva Houjeghani |
| collection | DOAJ |
| description | Background Polycystic ovary syndrome (PCOS) patients are more prone to abnormal production of some regulatory peptides. In these patients, studies on the serum levels of leptin and ghrelin are controversial. This study aims to investigate serum levels of leptin and ghrelin and their correlation with metabolic and endocrine indices in PCOS. Materials and Methods This case-control study was conducted on 60 women; 30 with PCOS and 30 healthy women whose age and body mass index (BMI) were matched and who were referred to Alzahra Hospital, Tabriz, Iran. Serum levels of leptin, ghrelin, insulin, luteinizing hormone (LH), follicle stimulating hormone (FSH), sex hormone-binding globulin (SHBG), and testosterone were measured. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Descriptive statistics and correlations were performed using SPSS 12.0 for Windows. Results In PCOS women, serum levels of leptin, insulin, HOMA-IR, testosterone, LH, and LH/FSH were significantly higher, while SHBG was lower than in healthy women. Ghrelin and FSH were similar in both groups. Serum levels of leptin correlated with BMI (r=0.85, p < 0.001), waist to hip ratio (WHR) (r=0.55, p < 0.01), insulin levels (r=0.85, p < 0.001) and HOMA-IR (r=0.67, p < 0.01), while ghrelin levels had an inverse association with testosterone (r=-0.32, p=0.04). Conclusion The results showed increased leptin levels while ghrelin remained unchanged in PCOS patients. In PCOS patients, leptin positively correlated with BMI, WHR, insulin, and insulin resistance, while ghrelin was only associated with serum testosterone levels. |
| first_indexed | 2024-12-22T19:57:21Z |
| format | Article |
| id | doaj.art-463fbb857c914c22b78c8df15eacf7a7 |
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| issn | 2008-076X 2008-0778 |
| language | English |
| last_indexed | 2024-12-22T19:57:21Z |
| publishDate | 2012-07-01 |
| publisher | Royan Institute (ACECR), Tehran |
| record_format | Article |
| series | International Journal of Fertility and Sterility |
| spelling | doaj.art-463fbb857c914c22b78c8df15eacf7a72022-12-21T18:14:24ZengRoyan Institute (ACECR), TehranInternational Journal of Fertility and Sterility2008-076X2008-07782012-07-016211712645133Serum Leptin and Ghrelin Levels in Women with Polycystic Ovary Syndrome: Correlation with Anthropometric, Metabolic, and Endocrine ParametersShiva Houjeghani0Bahram Pourghassem Gargari1Laya Farzadi2Students’ Research Committee, Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, IranNutritional Research Center, Department of Biochemistry and Diet Therapy, Faculty of Health and Nutrition, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Obstetrics and Gynecology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, IranBackground Polycystic ovary syndrome (PCOS) patients are more prone to abnormal production of some regulatory peptides. In these patients, studies on the serum levels of leptin and ghrelin are controversial. This study aims to investigate serum levels of leptin and ghrelin and their correlation with metabolic and endocrine indices in PCOS. Materials and Methods This case-control study was conducted on 60 women; 30 with PCOS and 30 healthy women whose age and body mass index (BMI) were matched and who were referred to Alzahra Hospital, Tabriz, Iran. Serum levels of leptin, ghrelin, insulin, luteinizing hormone (LH), follicle stimulating hormone (FSH), sex hormone-binding globulin (SHBG), and testosterone were measured. The homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Descriptive statistics and correlations were performed using SPSS 12.0 for Windows. Results In PCOS women, serum levels of leptin, insulin, HOMA-IR, testosterone, LH, and LH/FSH were significantly higher, while SHBG was lower than in healthy women. Ghrelin and FSH were similar in both groups. Serum levels of leptin correlated with BMI (r=0.85, p < 0.001), waist to hip ratio (WHR) (r=0.55, p < 0.01), insulin levels (r=0.85, p < 0.001) and HOMA-IR (r=0.67, p < 0.01), while ghrelin levels had an inverse association with testosterone (r=-0.32, p=0.04). Conclusion The results showed increased leptin levels while ghrelin remained unchanged in PCOS patients. In PCOS patients, leptin positively correlated with BMI, WHR, insulin, and insulin resistance, while ghrelin was only associated with serum testosterone levels.http://www.ijfs.ir/article_45133_06de73ba25b293e0f8ce85295acf392a.pdfpolycystic ovary syndromeleptinghrelininsulin |
| spellingShingle | Shiva Houjeghani Bahram Pourghassem Gargari Laya Farzadi Serum Leptin and Ghrelin Levels in Women with Polycystic Ovary Syndrome: Correlation with Anthropometric, Metabolic, and Endocrine Parameters International Journal of Fertility and Sterility polycystic ovary syndrome leptin ghrelin insulin |
| title | Serum Leptin and Ghrelin Levels in Women with Polycystic Ovary Syndrome: Correlation with Anthropometric, Metabolic, and Endocrine Parameters |
| title_full | Serum Leptin and Ghrelin Levels in Women with Polycystic Ovary Syndrome: Correlation with Anthropometric, Metabolic, and Endocrine Parameters |
| title_fullStr | Serum Leptin and Ghrelin Levels in Women with Polycystic Ovary Syndrome: Correlation with Anthropometric, Metabolic, and Endocrine Parameters |
| title_full_unstemmed | Serum Leptin and Ghrelin Levels in Women with Polycystic Ovary Syndrome: Correlation with Anthropometric, Metabolic, and Endocrine Parameters |
| title_short | Serum Leptin and Ghrelin Levels in Women with Polycystic Ovary Syndrome: Correlation with Anthropometric, Metabolic, and Endocrine Parameters |
| title_sort | serum leptin and ghrelin levels in women with polycystic ovary syndrome correlation with anthropometric metabolic and endocrine parameters |
| topic | polycystic ovary syndrome leptin ghrelin insulin |
| url | http://www.ijfs.ir/article_45133_06de73ba25b293e0f8ce85295acf392a.pdf |
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