CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization

CSF1R blockade induces macrophage ablation and results in mouse choroidal vascular atrophy and RPE disorganization

The choroid, which provides vascular supply to the outer retina, demonstrates progressive degeneration in aging and age-related macular degeneration (AMD). However mechanisms that maintain or compromise choroidal homeostasis are obscure. We discovered that the ablation of choroidal macrophages via C...

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Bibliographic Details
Main Authors: Xiao Yang, Lian Zhao, Maria M Campos, Mones Abu-Asab, Davide Ortolan, Nathan Hotaling, Kapil Bharti, Wai T Wong
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
choroidal macrophage
choroidal vasculature
RPE disorganization
choroid
aging
Online Access:https://elifesciences.org/articles/55564

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