What are NLRP3-ASC specks? an experimental progress of 22 years of inflammasome research
Speck assembly is the hallmark of NLRP3 inflammasome activation. The 1µm structure comprising of NLRP3 and ASC is the first observable phenotype of NLRP3 activation. While the common consensus is that the specks are the site of inflammasome activity, no direct experimental evidence exists to support...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1188864/full |
| _version_ | 1827892794504511488 |
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| author | Abhinit Nagar Ravi Bharadwaj Mohammad Omar Faruk Shaikh Mohammad Omar Faruk Shaikh Abhishek Roy |
| author_facet | Abhinit Nagar Ravi Bharadwaj Mohammad Omar Faruk Shaikh Mohammad Omar Faruk Shaikh Abhishek Roy |
| author_sort | Abhinit Nagar |
| collection | DOAJ |
| description | Speck assembly is the hallmark of NLRP3 inflammasome activation. The 1µm structure comprising of NLRP3 and ASC is the first observable phenotype of NLRP3 activation. While the common consensus is that the specks are the site of inflammasome activity, no direct experimental evidence exists to support this notion. In these 22 years, since the inflammasome discovery, several research studies have been published which directly or indirectly support or refute the idea of speck being the inflammasome. This review compiles the data from two decades of research to answer a long-standing question: “What are NLRP3-ASC specks?” |
| first_indexed | 2024-03-12T21:44:11Z |
| format | Article |
| id | doaj.art-46400b5a9fae437a9412c2a2ab32be1f |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-12T21:44:11Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-46400b5a9fae437a9412c2a2ab32be1f2023-07-26T13:05:01ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-07-011410.3389/fimmu.2023.11888641188864What are NLRP3-ASC specks? an experimental progress of 22 years of inflammasome researchAbhinit Nagar0Ravi Bharadwaj1Mohammad Omar Faruk Shaikh2Mohammad Omar Faruk Shaikh3Abhishek Roy4Department of Flow Cytometry, Cytek Biosciences, Fremont, CA, United StatesMassBiologics of the University of Massachusetts Medical School, Boston, MA, United StatesDivision of Critical Care Medicine, Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children’s Hospital, Boston, MA, United StatesDepartment of Anesthesia, Harvard Medical School, Boston, MA, United StatesDepartment of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United StatesSpeck assembly is the hallmark of NLRP3 inflammasome activation. The 1µm structure comprising of NLRP3 and ASC is the first observable phenotype of NLRP3 activation. While the common consensus is that the specks are the site of inflammasome activity, no direct experimental evidence exists to support this notion. In these 22 years, since the inflammasome discovery, several research studies have been published which directly or indirectly support or refute the idea of speck being the inflammasome. This review compiles the data from two decades of research to answer a long-standing question: “What are NLRP3-ASC specks?”https://www.frontiersin.org/articles/10.3389/fimmu.2023.1188864/fullASC specksSMOCsCasp-1NLRP3inflammasome |
| spellingShingle | Abhinit Nagar Ravi Bharadwaj Mohammad Omar Faruk Shaikh Mohammad Omar Faruk Shaikh Abhishek Roy What are NLRP3-ASC specks? an experimental progress of 22 years of inflammasome research Frontiers in Immunology ASC specks SMOCs Casp-1 NLRP3 inflammasome |
| title | What are NLRP3-ASC specks? an experimental progress of 22 years of inflammasome research |
| title_full | What are NLRP3-ASC specks? an experimental progress of 22 years of inflammasome research |
| title_fullStr | What are NLRP3-ASC specks? an experimental progress of 22 years of inflammasome research |
| title_full_unstemmed | What are NLRP3-ASC specks? an experimental progress of 22 years of inflammasome research |
| title_short | What are NLRP3-ASC specks? an experimental progress of 22 years of inflammasome research |
| title_sort | what are nlrp3 asc specks an experimental progress of 22 years of inflammasome research |
| topic | ASC specks SMOCs Casp-1 NLRP3 inflammasome |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1188864/full |
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