What are NLRP3-ASC specks? an experimental progress of 22 years of inflammasome research

What are NLRP3-ASC specks? an experimental progress of 22 years of inflammasome research

Speck assembly is the hallmark of NLRP3 inflammasome activation. The 1µm structure comprising of NLRP3 and ASC is the first observable phenotype of NLRP3 activation. While the common consensus is that the specks are the site of inflammasome activity, no direct experimental evidence exists to support...

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Bibliographic Details
Main Authors: Abhinit Nagar, Ravi Bharadwaj, Mohammad Omar Faruk Shaikh, Abhishek Roy
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Immunology
Subjects:
ASC specks
SMOCs
Casp-1
NLRP3
inflammasome
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1188864/full

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