PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine

PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine

Mitochondrial sterol 27-hydroxylase (CYP27A1) catalyzes oxidative cleavage of the sterol side chain in the bile acid biosynthetic pathway in the liver and 27-hydroxylation of cholesterol in most tissues. Recent studies suggest that 27-hydroxycholesterol (27-HOC) activates liver orphan receptor α (LX...

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Bibliographic Details
Main Authors:	Tiangang Li, Wenling Chen, John Y.L. Chiang
Format:	Article
Language:	English
Published:	Elsevier 2007-02-01
Series:	Journal of Lipid Research
Subjects:	bile acid synthesis oxysterols ATP binding cassette transporter A1 ATP binding cassette transporter G1 high density lipoprotein liver orphan receptor
Online Access:	http://www.sciencedirect.com/science/article/pii/S0022227520436739

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