Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.

Broadly neutralizing antibody PGT121 allosterically modulates CD4 binding via recognition of the HIV-1 gp120 V3 base and multiple surrounding glycans.

New broad and potent neutralizing HIV-1 antibodies have recently been described that are largely dependent on the gp120 N332 glycan for Env recognition. Members of the PGT121 family of antibodies, isolated from an African donor, neutralize ∼70% of circulating isolates with a median IC50 less than 0....

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Bibliographic Details
Main Authors: Jean-Philippe Julien, Devin Sok, Reza Khayat, Jeong Hyun Lee, Katie J Doores, Laura M Walker, Alejandra Ramos, Devan C Diwanji, Robert Pejchal, Albert Cupo, Umesh Katpally, Rafael S Depetris, Robyn L Stanfield, Ryan McBride, Andre J Marozsan, James C Paulson, Rogier W Sanders, John P Moore, Dennis R Burton, Pascal Poignard, Andrew B Ward, Ian A Wilson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3642082?pdf=render

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