Evaluation of the efficacy of excimer laser ablation of cross-linked porcine cornea.
BACKGROUND: Combination of riboflavin/UVA cross-linking (CXL) and excimer laser ablation is a promising therapy for treating corneal ectasia. The cornea is strengthened by cross-linking, while the irregular astigmatism is reduced by laser ablation. This study aims to compare the efficacy of excimer...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3463596?pdf=render |
| _version_ | 1818981220953882624 |
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| author | Shihao Chen Yini Li Aleksander Stojanovic Jia Zhang Yibo Wang Qinmei Wang Theo Seiler |
| author_facet | Shihao Chen Yini Li Aleksander Stojanovic Jia Zhang Yibo Wang Qinmei Wang Theo Seiler |
| author_sort | Shihao Chen |
| collection | DOAJ |
| description | BACKGROUND: Combination of riboflavin/UVA cross-linking (CXL) and excimer laser ablation is a promising therapy for treating corneal ectasia. The cornea is strengthened by cross-linking, while the irregular astigmatism is reduced by laser ablation. This study aims to compare the efficacy of excimer laser ablation on porcine corneas with and without cross-linking. METHODS AND FINDINGS: The porcine cornea was de-epithelialized and treated with 0.1% riboflavin solution for 30 minutes. A half of the cornea was exposed to UVA-radiation for another 30 minutes while the controlled half of the cornea was protected from the UVA using a metal shield. Photo therapeutic keratectomy (PTK) was then performed on the central cornea. Corneal thickness of 5 paired locations on the horizontal line, ± 0.5, ± 1.0, ± 1.5, ± 2.0, and ± 2.5 mm from the central spot, were measured using optical coherence tomography prior to and after PTK. The ablation depth was then determined by the corneal thickness. There was a 9% difference (P<0.001) in the overall ablation depth between the CXL-half corneas (158 ± 22 µm) and the control-half corneas (174 ± 26 µm). The ablation depths of all 5 correspondent locations on the CXL-half were significantly smaller (P<0.001). CONCLUSION: The efficacy of the laser ablation seems to be lower in cross-linked cornea. Current ablation algorithms may need to be modified for cross-linked corneas. |
| first_indexed | 2024-12-20T17:27:52Z |
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| id | doaj.art-46482ecd13ae49508bd8db3e5be65b87 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-20T17:27:52Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-46482ecd13ae49508bd8db3e5be65b872022-12-21T19:31:29ZengPublic Library of Science (PLoS)PLoS ONE1932-62032012-01-01710e4623210.1371/journal.pone.0046232Evaluation of the efficacy of excimer laser ablation of cross-linked porcine cornea.Shihao ChenYini LiAleksander StojanovicJia ZhangYibo WangQinmei WangTheo SeilerBACKGROUND: Combination of riboflavin/UVA cross-linking (CXL) and excimer laser ablation is a promising therapy for treating corneal ectasia. The cornea is strengthened by cross-linking, while the irregular astigmatism is reduced by laser ablation. This study aims to compare the efficacy of excimer laser ablation on porcine corneas with and without cross-linking. METHODS AND FINDINGS: The porcine cornea was de-epithelialized and treated with 0.1% riboflavin solution for 30 minutes. A half of the cornea was exposed to UVA-radiation for another 30 minutes while the controlled half of the cornea was protected from the UVA using a metal shield. Photo therapeutic keratectomy (PTK) was then performed on the central cornea. Corneal thickness of 5 paired locations on the horizontal line, ± 0.5, ± 1.0, ± 1.5, ± 2.0, and ± 2.5 mm from the central spot, were measured using optical coherence tomography prior to and after PTK. The ablation depth was then determined by the corneal thickness. There was a 9% difference (P<0.001) in the overall ablation depth between the CXL-half corneas (158 ± 22 µm) and the control-half corneas (174 ± 26 µm). The ablation depths of all 5 correspondent locations on the CXL-half were significantly smaller (P<0.001). CONCLUSION: The efficacy of the laser ablation seems to be lower in cross-linked cornea. Current ablation algorithms may need to be modified for cross-linked corneas.http://europepmc.org/articles/PMC3463596?pdf=render |
| spellingShingle | Shihao Chen Yini Li Aleksander Stojanovic Jia Zhang Yibo Wang Qinmei Wang Theo Seiler Evaluation of the efficacy of excimer laser ablation of cross-linked porcine cornea. PLoS ONE |
| title | Evaluation of the efficacy of excimer laser ablation of cross-linked porcine cornea. |
| title_full | Evaluation of the efficacy of excimer laser ablation of cross-linked porcine cornea. |
| title_fullStr | Evaluation of the efficacy of excimer laser ablation of cross-linked porcine cornea. |
| title_full_unstemmed | Evaluation of the efficacy of excimer laser ablation of cross-linked porcine cornea. |
| title_short | Evaluation of the efficacy of excimer laser ablation of cross-linked porcine cornea. |
| title_sort | evaluation of the efficacy of excimer laser ablation of cross linked porcine cornea |
| url | http://europepmc.org/articles/PMC3463596?pdf=render |
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