Magnetic Graphene Quantum Dots as a Functional Nanomaterial Towards Voltammetric Detection of L-tryptophan at Physiological pH
L-Tryptophan (L-Trp) is of great importance in the biochemical, pharmaceutical and dietetic fields as it is precursor molecule of some hormones, neurotransmitters and other relevant biomolecules. So, determination of this amino acid has important role in detection of some neuron based disease. The m...
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| Format: | Article |
| Language: | English |
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Nanoscience and Nanotechnology Research Center, University of Kashan
2018-01-01
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| Series: | Journal of Nanostructures |
| Subjects: | |
| Online Access: | http://jns.kashanu.ac.ir/article_55796_6fb126457fcb00321583f2e9d13d4ee4.pdf |
| _version_ | 1818119374001668096 |
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| author | Mohammad Hasanzadeh Ayub Karimzadeh Nasrin Shadjou |
| author_facet | Mohammad Hasanzadeh Ayub Karimzadeh Nasrin Shadjou |
| author_sort | Mohammad Hasanzadeh |
| collection | DOAJ |
| description | L-Tryptophan (L-Trp) is of great importance in the biochemical, pharmaceutical and dietetic fields as it is precursor molecule of some hormones, neurotransmitters and other relevant biomolecules. So, determination of this amino acid has important role in detection of some neuron based disease. The main purpose of this report was to develop application of Fe3O4 magnetic nanoparticles/graphene quantum dots (Fe3O4 MNP-GQDs)) as a nanosensor towards electrooxidation and determination of L-Trp and also the evaluation its kinetic parameters. In continuation of our efforts to use Fe3O4 MNP-GQDs for amino acids detection, our objective in the present work was to expand application of this sensor for the determination of L-Trp which is very sensitive. Decrease in oxidation overpotential and enhancement in current proved the electrocatalytic activity of Fe3O4 MNPs-GQDs-GCE as a sensor. Importantly, by this simple method of fabrication a much lower detection limit was achieved without involving any pre-treatment or activation steps. The analytical applicability of the modified electrode has been evaluated by successfully employing it for the determination of L-Trp in the standard solution. |
| first_indexed | 2024-12-11T05:09:11Z |
| format | Article |
| id | doaj.art-4649d2756f8a47f7853c7b0f5143bbf1 |
| institution | Directory Open Access Journal |
| issn | 2251-7871 2251-788X |
| language | English |
| last_indexed | 2024-12-11T05:09:11Z |
| publishDate | 2018-01-01 |
| publisher | Nanoscience and Nanotechnology Research Center, University of Kashan |
| record_format | Article |
| series | Journal of Nanostructures |
| spelling | doaj.art-4649d2756f8a47f7853c7b0f5143bbf12022-12-22T01:19:58ZengNanoscience and Nanotechnology Research Center, University of KashanJournal of Nanostructures2251-78712251-788X2018-01-0181213010.22052/JNS.2018.01.00355796Magnetic Graphene Quantum Dots as a Functional Nanomaterial Towards Voltammetric Detection of L-tryptophan at Physiological pHMohammad Hasanzadeh0Ayub Karimzadeh1Nasrin Shadjou2Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz 51664, IranPharmaceutical Analysis Research Center, Tabriz University of Medical Sciences, Tabriz 51656065811, Iran.Department of Nanochemistry, Nano Technology Research Center, Urmia University, Urmia 57154, Iran| Department of Nano Technology, Faculty of Science, Urmia University, Urmia 57154, Iran.L-Tryptophan (L-Trp) is of great importance in the biochemical, pharmaceutical and dietetic fields as it is precursor molecule of some hormones, neurotransmitters and other relevant biomolecules. So, determination of this amino acid has important role in detection of some neuron based disease. The main purpose of this report was to develop application of Fe3O4 magnetic nanoparticles/graphene quantum dots (Fe3O4 MNP-GQDs)) as a nanosensor towards electrooxidation and determination of L-Trp and also the evaluation its kinetic parameters. In continuation of our efforts to use Fe3O4 MNP-GQDs for amino acids detection, our objective in the present work was to expand application of this sensor for the determination of L-Trp which is very sensitive. Decrease in oxidation overpotential and enhancement in current proved the electrocatalytic activity of Fe3O4 MNPs-GQDs-GCE as a sensor. Importantly, by this simple method of fabrication a much lower detection limit was achieved without involving any pre-treatment or activation steps. The analytical applicability of the modified electrode has been evaluated by successfully employing it for the determination of L-Trp in the standard solution.http://jns.kashanu.ac.ir/article_55796_6fb126457fcb00321583f2e9d13d4ee4.pdfamino acidgraphene quantum dotl-tryptophanmagnetic nanoparticle |
| spellingShingle | Mohammad Hasanzadeh Ayub Karimzadeh Nasrin Shadjou Magnetic Graphene Quantum Dots as a Functional Nanomaterial Towards Voltammetric Detection of L-tryptophan at Physiological pH Journal of Nanostructures amino acid graphene quantum dot l-tryptophan magnetic nanoparticle |
| title | Magnetic Graphene Quantum Dots as a Functional Nanomaterial Towards Voltammetric Detection of L-tryptophan at Physiological pH |
| title_full | Magnetic Graphene Quantum Dots as a Functional Nanomaterial Towards Voltammetric Detection of L-tryptophan at Physiological pH |
| title_fullStr | Magnetic Graphene Quantum Dots as a Functional Nanomaterial Towards Voltammetric Detection of L-tryptophan at Physiological pH |
| title_full_unstemmed | Magnetic Graphene Quantum Dots as a Functional Nanomaterial Towards Voltammetric Detection of L-tryptophan at Physiological pH |
| title_short | Magnetic Graphene Quantum Dots as a Functional Nanomaterial Towards Voltammetric Detection of L-tryptophan at Physiological pH |
| title_sort | magnetic graphene quantum dots as a functional nanomaterial towards voltammetric detection of l tryptophan at physiological ph |
| topic | amino acid graphene quantum dot l-tryptophan magnetic nanoparticle |
| url | http://jns.kashanu.ac.ir/article_55796_6fb126457fcb00321583f2e9d13d4ee4.pdf |
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