Adverse Drug Reactions and Anaesthesia: A Narrative Review
Adverse drug reactions are defined as the effects created by drugs producing unintended or noxious response in doses normally used for prophylaxis, diagnosis or therapy of diseases. Adverse drug reactions under anaesthesia occur by a number of mechanisms and several risk factors are often involved....
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2022-07-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://www.jcdr.net/articles/PDF/16567/55703_CE[Nik]_F[SH]_PF1(SC_KM)_PFA(SC_KM)_PN(KM).pdf |
| _version_ | 1797903931786919936 |
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| author | Ramyavel Thangavelu RV Ranjan |
| author_facet | Ramyavel Thangavelu RV Ranjan |
| author_sort | Ramyavel Thangavelu |
| collection | DOAJ |
| description | Adverse drug reactions are defined as the effects created by drugs producing unintended or noxious response in doses normally used for prophylaxis, diagnosis or therapy of diseases. Adverse drug reactions under anaesthesia occur by a number of mechanisms and several risk factors are often involved. The overall incidence of adverse drug reactions to anaesthetic drugs ranges between 1 in 10,000 and 1 in 20,000. Electronic databases were searched to obtain the relevant literature with keywords related to adverse drug reactions and anaesthesia. Total 110 articles were reviewed, bibliography cross-checked and relevant literature was included. This article discusses about the adverse drug reactions to various anaesthetic as well as non anaesthetic drugs used intraoperatively. Anaphylaxis under anaesthesia, its pathophysiology, clinical and laboratory diagnosis, management and prevention has also been discussed in detail. Allergic drug reactions and anaphylaxis in the operating room often presents unique diagnostic concerns as the early signs of anaphylaxis are often masked under general anaesthesia. The use of surgical drapes and use of multiple potential allergen drugs under anaesthesia also make the diagnostic process difficult. Thus, an adequate knowledge, understanding, vigilance and proper documentation with reporting in case of an event is warranted by the attending anaesthesiologist for a good perioperative outcome with decreased morbidity and mortality. |
| first_indexed | 2024-04-10T09:40:40Z |
| format | Article |
| id | doaj.art-4649e6db14e7489ba050623324f02934 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-04-10T09:40:40Z |
| publishDate | 2022-07-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-4649e6db14e7489ba050623324f029342023-02-17T10:17:35ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2022-07-01167UE01UE0710.7860/JCDR/2022/55703.16567Adverse Drug Reactions and Anaesthesia: A Narrative ReviewRamyavel Thangavelu0RV Ranjan1Associate Professor, Department of Anaesthesiology, Pondicherry Institute of Medical Sciences, Puducherry, India.Professor and Head, Department of Anaesthesiology, Pondicherry Institute of Medical Sciences, Puducherry, India.Adverse drug reactions are defined as the effects created by drugs producing unintended or noxious response in doses normally used for prophylaxis, diagnosis or therapy of diseases. Adverse drug reactions under anaesthesia occur by a number of mechanisms and several risk factors are often involved. The overall incidence of adverse drug reactions to anaesthetic drugs ranges between 1 in 10,000 and 1 in 20,000. Electronic databases were searched to obtain the relevant literature with keywords related to adverse drug reactions and anaesthesia. Total 110 articles were reviewed, bibliography cross-checked and relevant literature was included. This article discusses about the adverse drug reactions to various anaesthetic as well as non anaesthetic drugs used intraoperatively. Anaphylaxis under anaesthesia, its pathophysiology, clinical and laboratory diagnosis, management and prevention has also been discussed in detail. Allergic drug reactions and anaphylaxis in the operating room often presents unique diagnostic concerns as the early signs of anaphylaxis are often masked under general anaesthesia. The use of surgical drapes and use of multiple potential allergen drugs under anaesthesia also make the diagnostic process difficult. Thus, an adequate knowledge, understanding, vigilance and proper documentation with reporting in case of an event is warranted by the attending anaesthesiologist for a good perioperative outcome with decreased morbidity and mortality.https://www.jcdr.net/articles/PDF/16567/55703_CE[Nik]_F[SH]_PF1(SC_KM)_PFA(SC_KM)_PN(KM).pdfallergen drugsallergic reactionsdrug eventsoperating room |
| spellingShingle | Ramyavel Thangavelu RV Ranjan Adverse Drug Reactions and Anaesthesia: A Narrative Review Journal of Clinical and Diagnostic Research allergen drugs allergic reactions drug events operating room |
| title | Adverse Drug Reactions and Anaesthesia: A Narrative Review |
| title_full | Adverse Drug Reactions and Anaesthesia: A Narrative Review |
| title_fullStr | Adverse Drug Reactions and Anaesthesia: A Narrative Review |
| title_full_unstemmed | Adverse Drug Reactions and Anaesthesia: A Narrative Review |
| title_short | Adverse Drug Reactions and Anaesthesia: A Narrative Review |
| title_sort | adverse drug reactions and anaesthesia a narrative review |
| topic | allergen drugs allergic reactions drug events operating room |
| url | https://www.jcdr.net/articles/PDF/16567/55703_CE[Nik]_F[SH]_PF1(SC_KM)_PFA(SC_KM)_PN(KM).pdf |
| work_keys_str_mv | AT ramyavelthangavelu adversedrugreactionsandanaesthesiaanarrativereview AT rvranjan adversedrugreactionsandanaesthesiaanarrativereview |