CDK1/2/5 blockade: killing two birds with one stone

CDK1/2/5 blockade: killing two birds with one stone

Pancreatic ductal adenocarcinoma (PDAC) is an immune resistant tumor. We recently demonstrated that inhibiting CDK1/2/5 by dinaciclib not only blocks immune checkpoint expression, but also triggers histone-dependent immunogenic cell death. This dual mechanism turns immunologically “cold” tumor micro...

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Bibliographic Details
Main Authors: Jiao Liu, Rui Kang, Daolin Tang
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:OncoImmunology
Subjects:
apoptosis
cdk
dinaciclib
histone
immune checkpoint
immunogenic cell death
immunotherapy
pancreatic cancer
Online Access:http://dx.doi.org/10.1080/2162402X.2021.1875612

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