Antibacterial Alkaloids and Polyketide Derivatives from the Deep Sea-Derived Fungus <i>Penicillium cyclopium</i> SD-413
Nine secondary metabolites (<b>1</b>–<b>9</b>), including two new polyketide derivatives 9-dehydroxysargassopenilline A (<b>4</b>) and 1,2-didehydropeaurantiogriseol E (<b>5</b>), along with seven known related secondary metabolites (<b>1</b&g...
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| Format: | Article |
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MDPI AG
2020-11-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/18/11/553 |
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| author | Yan-He Li Xiao-Ming Li Xin Li Sui-Qun Yang Xiao-Shan Shi Hong-Lei Li Bin-Gui Wang |
| author_facet | Yan-He Li Xiao-Ming Li Xin Li Sui-Qun Yang Xiao-Shan Shi Hong-Lei Li Bin-Gui Wang |
| author_sort | Yan-He Li |
| collection | DOAJ |
| description | Nine secondary metabolites (<b>1</b>–<b>9</b>), including two new polyketide derivatives 9-dehydroxysargassopenilline A (<b>4</b>) and 1,2-didehydropeaurantiogriseol E (<b>5</b>), along with seven known related secondary metabolites (<b>1</b>–<b>3</b> and <b>6</b>–<b>9</b>), were isolated and identified from the deep sea-derived fungus <i>Penicillium</i><i>cyclopium</i> SD-413. Their structures were elucidated on the basis of 1D/2D NMR spectroscopic and mass spectrometric analysis and the absolute configurations were determined by the combination of NOESY correlations and time-dependent density functional (TDDFT) ECD calculations. Compounds <b>1</b>–<b>9</b> inhibited some pathogenic bacteria including <i>Escherichia coli</i>, <i>E. ictaluri</i>, <i>Edwardsiella tarda</i>, <i>Micrococcus luteus</i>, <i>Vibrio anguillarum</i>, and <i>V. harveyi</i>, with MIC (minimum inhibitory concentration) values ranging from 4 to 32 μg/mL. |
| first_indexed | 2024-03-10T15:02:01Z |
| format | Article |
| id | doaj.art-464d018d2f1d4877ba008918a77a054c |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T15:02:01Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-464d018d2f1d4877ba008918a77a054c2023-11-20T20:04:40ZengMDPI AGMarine Drugs1660-33972020-11-01181155310.3390/md18110553Antibacterial Alkaloids and Polyketide Derivatives from the Deep Sea-Derived Fungus <i>Penicillium cyclopium</i> SD-413Yan-He Li0Xiao-Ming Li1Xin Li2Sui-Qun Yang3Xiao-Shan Shi4Hong-Lei Li5Bin-Gui Wang6Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, ChinaKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, ChinaKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, ChinaKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, ChinaKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, ChinaKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, ChinaKey Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, ChinaNine secondary metabolites (<b>1</b>–<b>9</b>), including two new polyketide derivatives 9-dehydroxysargassopenilline A (<b>4</b>) and 1,2-didehydropeaurantiogriseol E (<b>5</b>), along with seven known related secondary metabolites (<b>1</b>–<b>3</b> and <b>6</b>–<b>9</b>), were isolated and identified from the deep sea-derived fungus <i>Penicillium</i><i>cyclopium</i> SD-413. Their structures were elucidated on the basis of 1D/2D NMR spectroscopic and mass spectrometric analysis and the absolute configurations were determined by the combination of NOESY correlations and time-dependent density functional (TDDFT) ECD calculations. Compounds <b>1</b>–<b>9</b> inhibited some pathogenic bacteria including <i>Escherichia coli</i>, <i>E. ictaluri</i>, <i>Edwardsiella tarda</i>, <i>Micrococcus luteus</i>, <i>Vibrio anguillarum</i>, and <i>V. harveyi</i>, with MIC (minimum inhibitory concentration) values ranging from 4 to 32 μg/mL.https://www.mdpi.com/1660-3397/18/11/553<i>Penicillium cyclopium</i>marine sediment-derived fungusquinazoline alkaloidpolyketide derivativesantibacterial activity |
| spellingShingle | Yan-He Li Xiao-Ming Li Xin Li Sui-Qun Yang Xiao-Shan Shi Hong-Lei Li Bin-Gui Wang Antibacterial Alkaloids and Polyketide Derivatives from the Deep Sea-Derived Fungus <i>Penicillium cyclopium</i> SD-413 Marine Drugs <i>Penicillium cyclopium</i> marine sediment-derived fungus quinazoline alkaloid polyketide derivatives antibacterial activity |
| title | Antibacterial Alkaloids and Polyketide Derivatives from the Deep Sea-Derived Fungus <i>Penicillium cyclopium</i> SD-413 |
| title_full | Antibacterial Alkaloids and Polyketide Derivatives from the Deep Sea-Derived Fungus <i>Penicillium cyclopium</i> SD-413 |
| title_fullStr | Antibacterial Alkaloids and Polyketide Derivatives from the Deep Sea-Derived Fungus <i>Penicillium cyclopium</i> SD-413 |
| title_full_unstemmed | Antibacterial Alkaloids and Polyketide Derivatives from the Deep Sea-Derived Fungus <i>Penicillium cyclopium</i> SD-413 |
| title_short | Antibacterial Alkaloids and Polyketide Derivatives from the Deep Sea-Derived Fungus <i>Penicillium cyclopium</i> SD-413 |
| title_sort | antibacterial alkaloids and polyketide derivatives from the deep sea derived fungus i penicillium cyclopium i sd 413 |
| topic | <i>Penicillium cyclopium</i> marine sediment-derived fungus quinazoline alkaloid polyketide derivatives antibacterial activity |
| url | https://www.mdpi.com/1660-3397/18/11/553 |
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