Post-transplant cyclophosphamide prevents xenogeneic graft-versus-host disease while depleting proliferating regulatory T cells

Post-transplant cyclophosphamide prevents xenogeneic graft-versus-host disease while depleting proliferating regulatory T cells

Summary: Graft-versus-host disease (GVHD) remains a serious limitation of allogeneic hematopoietic cell transplantation (allo-HCT). While post-transplant administration of cyclophosphamide (PTCy) is increasingly used as GVHD prophylaxis, its precise mechanisms of action and its impact on graft-versu...

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Bibliographic Details
Main Authors: Caroline Ritacco, Murat Cem Köse, Justine Courtois, Lorenzo Canti, Charline Beguin, Sophie Dubois, Benoît Vandenhove, Sophie Servais, Jo Caers, Yves Beguin, Grégory Ehx, Frédéric Baron
Format: Article
Language:English
Published: Elsevier 2023-03-01
Series:iScience
Subjects:
Medicine
Molecular biology
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223001621

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