Palliative radiotherapy in symptomatic locally advanced gastric cancer: A phase II trial
Abstract To evaluate the response and quality of life of palliative gastric radiotherapy in patients with symptomatic locally advanced gastric cancer. Patients with bleeding, pain or obstruction and were treated with palliative gastric radiotherapy to a dose of 36 Gy in 12 daily fractions. The prima...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2019-04-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.2021 |
| _version_ | 1827580509946904576 |
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| author | Jeremy Tey Huili Zheng Yu Y. Soon Cheng N. Leong Wee Y. Koh Keith Lim Jimmy B. Y. So Asim Shabbir Ivan W. K. Tham Jiade Lu |
| author_facet | Jeremy Tey Huili Zheng Yu Y. Soon Cheng N. Leong Wee Y. Koh Keith Lim Jimmy B. Y. So Asim Shabbir Ivan W. K. Tham Jiade Lu |
| author_sort | Jeremy Tey |
| collection | DOAJ |
| description | Abstract To evaluate the response and quality of life of palliative gastric radiotherapy in patients with symptomatic locally advanced gastric cancer. Patients with bleeding, pain or obstruction and were treated with palliative gastric radiotherapy to a dose of 36 Gy in 12 daily fractions. The primary outcomes were symptom response rates. Secondary outcomes included overall survival, adverse events and proportion of patients with ≥10‐point absolute improvement in the fatigue, nausea/vomiting and pain subscales in the EORTC Qualify of Life Questionnaire C30 (EORTC QLQ‐C30) and dysphagia/pain subscales in the gastric specific module (STO22) at the end of RT and 1 month after the completion of radiotherapy. Fifty patients were accrued. Median survival duration was 85 days. 40/50 patients (80%) with bleeding, 2/2 (100%) patients with obstruction and 1/1 (100%) patient with pain responded to radiotherapy. Improvements fatigue, nausea/vomiting and pain subscales of the EORTC QLQ‐C30 was seen in 50%, 28% and 44% of patients at the end of RT and in 63%, 31% and 50% of patients 1 month after RT. Improvements in dysphagia/pain subscales of the STO22 was seen in 42% and 28% of patients at then end of RT and 44% and 19% of patients 1 month after RT. Two patients (5%) had grade 3 anorexia and gastritis. Palliative gastric radiotherapy was effective, well tolerated and resulted in improvement in fatigue, dysphagia and pain at the end of radiotherapy and 1 month after the completion of radiotherapy in a significant proportion of patients. |
| first_indexed | 2024-03-08T22:20:05Z |
| format | Article |
| id | doaj.art-464e52b4a8a349d0a308bd16cdf22e17 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-03-08T22:20:05Z |
| publishDate | 2019-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-464e52b4a8a349d0a308bd16cdf22e172023-12-18T12:55:50ZengWileyCancer Medicine2045-76342019-04-01841447145810.1002/cam4.2021Palliative radiotherapy in symptomatic locally advanced gastric cancer: A phase II trialJeremy Tey0Huili Zheng1Yu Y. Soon2Cheng N. Leong3Wee Y. Koh4Keith Lim5Jimmy B. Y. So6Asim Shabbir7Ivan W. K. Tham8Jiade Lu9Department of Radiation Oncology National University Hospital National Cancer Institute of Singapore Singapore SingaporeNational Registry of Diseases Singapore SingaporeDepartment of Radiation Oncology National University Hospital National Cancer Institute of Singapore Singapore SingaporeDepartment of Radiation Oncology National University Hospital National Cancer Institute of Singapore Singapore SingaporeDepartment of Radiation Oncology National University Hospital National Cancer Institute of Singapore Singapore SingaporeDepartment of Radiation Oncology National University Hospital National Cancer Institute of Singapore Singapore SingaporeDepartment of Surgery National University Hospital Singapore SingaporeDepartment of Surgery National University Hospital Singapore SingaporeDepartment of Radiation Oncology National University Hospital National Cancer Institute of Singapore Singapore SingaporeShanghai Heavy ion and Proton Centre Shanghai ChinaAbstract To evaluate the response and quality of life of palliative gastric radiotherapy in patients with symptomatic locally advanced gastric cancer. Patients with bleeding, pain or obstruction and were treated with palliative gastric radiotherapy to a dose of 36 Gy in 12 daily fractions. The primary outcomes were symptom response rates. Secondary outcomes included overall survival, adverse events and proportion of patients with ≥10‐point absolute improvement in the fatigue, nausea/vomiting and pain subscales in the EORTC Qualify of Life Questionnaire C30 (EORTC QLQ‐C30) and dysphagia/pain subscales in the gastric specific module (STO22) at the end of RT and 1 month after the completion of radiotherapy. Fifty patients were accrued. Median survival duration was 85 days. 40/50 patients (80%) with bleeding, 2/2 (100%) patients with obstruction and 1/1 (100%) patient with pain responded to radiotherapy. Improvements fatigue, nausea/vomiting and pain subscales of the EORTC QLQ‐C30 was seen in 50%, 28% and 44% of patients at the end of RT and in 63%, 31% and 50% of patients 1 month after RT. Improvements in dysphagia/pain subscales of the STO22 was seen in 42% and 28% of patients at then end of RT and 44% and 19% of patients 1 month after RT. Two patients (5%) had grade 3 anorexia and gastritis. Palliative gastric radiotherapy was effective, well tolerated and resulted in improvement in fatigue, dysphagia and pain at the end of radiotherapy and 1 month after the completion of radiotherapy in a significant proportion of patients.https://doi.org/10.1002/cam4.2021bleedinggastric cancerpalliativeradiotherapy |
| spellingShingle | Jeremy Tey Huili Zheng Yu Y. Soon Cheng N. Leong Wee Y. Koh Keith Lim Jimmy B. Y. So Asim Shabbir Ivan W. K. Tham Jiade Lu Palliative radiotherapy in symptomatic locally advanced gastric cancer: A phase II trial Cancer Medicine bleeding gastric cancer palliative radiotherapy |
| title | Palliative radiotherapy in symptomatic locally advanced gastric cancer: A phase II trial |
| title_full | Palliative radiotherapy in symptomatic locally advanced gastric cancer: A phase II trial |
| title_fullStr | Palliative radiotherapy in symptomatic locally advanced gastric cancer: A phase II trial |
| title_full_unstemmed | Palliative radiotherapy in symptomatic locally advanced gastric cancer: A phase II trial |
| title_short | Palliative radiotherapy in symptomatic locally advanced gastric cancer: A phase II trial |
| title_sort | palliative radiotherapy in symptomatic locally advanced gastric cancer a phase ii trial |
| topic | bleeding gastric cancer palliative radiotherapy |
| url | https://doi.org/10.1002/cam4.2021 |
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