Effectiveness of hyaluronic acid-based anti-adhesion gel for intraoperative prevention of postoperative adhesions in surgical correction of distal occlusion of the fallopian tubes: Prospective cohort study
Aim. To evaluate the effectiveness of hyaluronic acid anti-adhesion gel in surgical correction of distal tubal occlusion in restoring natural fertility in patients with infertility. Materials and methods. A prospective cohort study was conducted. The main group (group 1) included 54 women; the co...
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| Format: | Article |
| Language: | Russian |
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IP Berlin A.V.
2023-07-01
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| Series: | Гинекология |
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| Online Access: | https://gynecology.orscience.ru/2079-5831/article/viewFile/546114/132541 |
| _version_ | 1797772999692124160 |
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| author | Sergey V. Rybnikov Natalia V. Artymuk |
| author_facet | Sergey V. Rybnikov Natalia V. Artymuk |
| author_sort | Sergey V. Rybnikov |
| collection | DOAJ |
| description | Aim. To evaluate the effectiveness of hyaluronic acid anti-adhesion gel in surgical correction of distal tubal occlusion in restoring natural fertility in patients with infertility.
Materials and methods. A prospective cohort study was conducted. The main group (group 1) included 54 women; the comparison group (group 2) included 58 women with tuboperitoneal infertility due to distal occlusion of the fallopian tubes. In group 1 patients, at the final stage of endoscopic reconstructive plastic surgery on the surface of the fallopian tubes, anti-adhesion barrier Anti-adhesion was applied (5 mL per each operated fallopian tube). Primary outcomes (patency of the fallopian tubes after 3 months) and secondary outcomes (onset of uterine pregnancy during the first year) were assessed. Statistical results were processed using the IBM SPSS Statistics version 25.0 software package.
Results. Within 3 months after surgical treatment, the patency of the fallopian tubes was reported in 32 (59.3%) group 1 patients and 24 (41.4%) group 2 patients (2=3.445; p=0.064). The rate of uterine pregnancy in group 1 during the first year after surgical treatment was significantly higher than in group 2: 21 (38.9%) and 12 (20.7%) women, respectively (2=4.447; p=0.035).
Conclusion. Endoscopic reconstructive plastic surgeries using hyaluronic acid-based anti-adhesion gel in patients with distal tubal occlusion slightly reduces the frequency of postoperative reocclusions of the fallopian tubes within 3 months after surgical treatment and significantly increase the rate of uterine pregnancy during the year after surgery mainly due to patients with grade IIIIV of adhesive process in the pelvis. |
| first_indexed | 2024-03-12T21:59:53Z |
| format | Article |
| id | doaj.art-464f72b0e4604bd3acc9e580862d4251 |
| institution | Directory Open Access Journal |
| issn | 2079-5696 2079-5831 |
| language | Russian |
| last_indexed | 2024-03-12T21:59:53Z |
| publishDate | 2023-07-01 |
| publisher | IP Berlin A.V. |
| record_format | Article |
| series | Гинекология |
| spelling | doaj.art-464f72b0e4604bd3acc9e580862d42512023-07-25T09:21:27ZrusIP Berlin A.V.Гинекология2079-56962079-58312023-07-0125222222610.26442/20795696.2023.2.20223579518Effectiveness of hyaluronic acid-based anti-adhesion gel for intraoperative prevention of postoperative adhesions in surgical correction of distal occlusion of the fallopian tubes: Prospective cohort studySergey V. Rybnikov0https://orcid.org/0000-0002-4229-6781Natalia V. Artymuk1https://orcid.org/0000-0001-7014-6492Kemerovo State Medical UniversityKemerovo State Medical UniversityAim. To evaluate the effectiveness of hyaluronic acid anti-adhesion gel in surgical correction of distal tubal occlusion in restoring natural fertility in patients with infertility. Materials and methods. A prospective cohort study was conducted. The main group (group 1) included 54 women; the comparison group (group 2) included 58 women with tuboperitoneal infertility due to distal occlusion of the fallopian tubes. In group 1 patients, at the final stage of endoscopic reconstructive plastic surgery on the surface of the fallopian tubes, anti-adhesion barrier Anti-adhesion was applied (5 mL per each operated fallopian tube). Primary outcomes (patency of the fallopian tubes after 3 months) and secondary outcomes (onset of uterine pregnancy during the first year) were assessed. Statistical results were processed using the IBM SPSS Statistics version 25.0 software package. Results. Within 3 months after surgical treatment, the patency of the fallopian tubes was reported in 32 (59.3%) group 1 patients and 24 (41.4%) group 2 patients (2=3.445; p=0.064). The rate of uterine pregnancy in group 1 during the first year after surgical treatment was significantly higher than in group 2: 21 (38.9%) and 12 (20.7%) women, respectively (2=4.447; p=0.035). Conclusion. Endoscopic reconstructive plastic surgeries using hyaluronic acid-based anti-adhesion gel in patients with distal tubal occlusion slightly reduces the frequency of postoperative reocclusions of the fallopian tubes within 3 months after surgical treatment and significantly increase the rate of uterine pregnancy during the year after surgery mainly due to patients with grade IIIIV of adhesive process in the pelvis.https://gynecology.orscience.ru/2079-5831/article/viewFile/546114/132541anti-adhesionhyaluronic acid-bases anti-adhesion gelsurgical correctiondistal occlusionpostoperative adhesionstuboperitoneal infertilitysalpingostomy |
| spellingShingle | Sergey V. Rybnikov Natalia V. Artymuk Effectiveness of hyaluronic acid-based anti-adhesion gel for intraoperative prevention of postoperative adhesions in surgical correction of distal occlusion of the fallopian tubes: Prospective cohort study Гинекология anti-adhesion hyaluronic acid-bases anti-adhesion gel surgical correction distal occlusion postoperative adhesions tuboperitoneal infertility salpingostomy |
| title | Effectiveness of hyaluronic acid-based anti-adhesion gel for intraoperative prevention of postoperative adhesions in surgical correction of distal occlusion of the fallopian tubes: Prospective cohort study |
| title_full | Effectiveness of hyaluronic acid-based anti-adhesion gel for intraoperative prevention of postoperative adhesions in surgical correction of distal occlusion of the fallopian tubes: Prospective cohort study |
| title_fullStr | Effectiveness of hyaluronic acid-based anti-adhesion gel for intraoperative prevention of postoperative adhesions in surgical correction of distal occlusion of the fallopian tubes: Prospective cohort study |
| title_full_unstemmed | Effectiveness of hyaluronic acid-based anti-adhesion gel for intraoperative prevention of postoperative adhesions in surgical correction of distal occlusion of the fallopian tubes: Prospective cohort study |
| title_short | Effectiveness of hyaluronic acid-based anti-adhesion gel for intraoperative prevention of postoperative adhesions in surgical correction of distal occlusion of the fallopian tubes: Prospective cohort study |
| title_sort | effectiveness of hyaluronic acid based anti adhesion gel for intraoperative prevention of postoperative adhesions in surgical correction of distal occlusion of the fallopian tubes prospective cohort study |
| topic | anti-adhesion hyaluronic acid-bases anti-adhesion gel surgical correction distal occlusion postoperative adhesions tuboperitoneal infertility salpingostomy |
| url | https://gynecology.orscience.ru/2079-5831/article/viewFile/546114/132541 |
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