BDNF Regulates the Expression of Fragile X Mental Retardation Protein mRNA in the Hippocampus

BDNF Regulates the Expression of Fragile X Mental Retardation Protein mRNA in the Hippocampus

Both fragile X mental retardation protein (FMRP) and brain-derived neurotrophic factor (BDNF) are implicated in the maturation of neurons and in the higher cognitive functions. We have investigated whether FMRP and BDNF are reciprocally regulated in neurons. Exposure of cultured hippocampal neurons...

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Bibliographic Details
Main Authors: Maija Castrén, Katariina E Lampinen, Riitta Miettinen, Eija Koponen, Ilkka Sipola, Cathy E Bakker, Ben A Oostra, Eero Castrén
Format: Article
Language:English
Published: Elsevier 2002-10-01
Series:Neurobiology of Disease
Subjects:
fragile X syndrome
Fmr1
brain-derived neurotrophic factor
TrkB
gene expression
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102905449

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