Overview of aristolochic acid nephropathy: an update
Aristolochic acid nephropathy (AAN) is a rapidly progressive renal interstitial fibrosis caused by medical or environmental exposure to aristolochic acid (AA). Since the outbreak of AAN in Belgium was reported nearly 30 years ago, the safety of herbal remedies has drawn considerable attention, and A...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2023-09-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | http://krcp-ksn.org/upload/pdf/j-krcp-22-211.pdf |
| _version_ | 1797628837234737152 |
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| author | Qingqing Zhou Lei Jiang Tao Su Gang Liu Li Yang |
| author_facet | Qingqing Zhou Lei Jiang Tao Su Gang Liu Li Yang |
| author_sort | Qingqing Zhou |
| collection | DOAJ |
| description | Aristolochic acid nephropathy (AAN) is a rapidly progressive renal interstitial fibrosis caused by medical or environmental exposure to aristolochic acid (AA). Since the outbreak of AAN in Belgium was reported nearly 30 years ago, the safety of herbal remedies has drawn considerable attention, and AAN has become a global public health problem. Breakthroughs have been made to better understand the disease, including the toxicity of AAs, the possible mechanisms of AAN, the disease patterns, and the pathological features; however, some critical problems remain unresolved. Because of the insidious onset of the disease, the incidence of AAN and the prevalence of exposure to AAs are unknown and might be largely underestimated. During the past decades, AA-containing herbs have been strictly administrated in many regions and the occurrence of AAN has declined sharply, yet cases of AAN are still sporadically reported. Despite the progress in the understanding of the disease’s pathogenesis, there is no effective treatment for delaying or reversing the renal deterioration caused by AAN. Therefore, the risk of exposure to AAs should be taken seriously by public health workers and clinicians. In this review, we updated the latest data on AAN, summarized the advances throughout these years, and put forward some challenges for future research. |
| first_indexed | 2024-03-11T10:44:48Z |
| format | Article |
| id | doaj.art-4650601ef9a2468d911d466abb2e7678 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 2211-9140 |
| language | English |
| last_indexed | 2024-03-11T10:44:48Z |
| publishDate | 2023-09-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-4650601ef9a2468d911d466abb2e76782023-11-14T07:03:34ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322211-91402023-09-0142557959010.23876/j.krcp.22.2116230Overview of aristolochic acid nephropathy: an updateQingqing Zhou0Lei Jiang1Tao Su2Gang Liu3Li Yang4 Division of Renal, Department of Medicine, Peking University First Hospital, Beijing, China Division of Renal, Department of Medicine, Peking University First Hospital, Beijing, China Division of Renal, Department of Medicine, Peking University First Hospital, Beijing, China Division of Renal, Department of Medicine, Peking University First Hospital, Beijing, China Division of Renal, Department of Medicine, Peking University First Hospital, Beijing, ChinaAristolochic acid nephropathy (AAN) is a rapidly progressive renal interstitial fibrosis caused by medical or environmental exposure to aristolochic acid (AA). Since the outbreak of AAN in Belgium was reported nearly 30 years ago, the safety of herbal remedies has drawn considerable attention, and AAN has become a global public health problem. Breakthroughs have been made to better understand the disease, including the toxicity of AAs, the possible mechanisms of AAN, the disease patterns, and the pathological features; however, some critical problems remain unresolved. Because of the insidious onset of the disease, the incidence of AAN and the prevalence of exposure to AAs are unknown and might be largely underestimated. During the past decades, AA-containing herbs have been strictly administrated in many regions and the occurrence of AAN has declined sharply, yet cases of AAN are still sporadically reported. Despite the progress in the understanding of the disease’s pathogenesis, there is no effective treatment for delaying or reversing the renal deterioration caused by AAN. Therefore, the risk of exposure to AAs should be taken seriously by public health workers and clinicians. In this review, we updated the latest data on AAN, summarized the advances throughout these years, and put forward some challenges for future research.http://krcp-ksn.org/upload/pdf/j-krcp-22-211.pdfaristolochic acidsaristolochic acid nephropathyherbal therapyinterstitial nephropathyrenal tubular dysfunction |
| spellingShingle | Qingqing Zhou Lei Jiang Tao Su Gang Liu Li Yang Overview of aristolochic acid nephropathy: an update Kidney Research and Clinical Practice aristolochic acids aristolochic acid nephropathy herbal therapy interstitial nephropathy renal tubular dysfunction |
| title | Overview of aristolochic acid nephropathy: an update |
| title_full | Overview of aristolochic acid nephropathy: an update |
| title_fullStr | Overview of aristolochic acid nephropathy: an update |
| title_full_unstemmed | Overview of aristolochic acid nephropathy: an update |
| title_short | Overview of aristolochic acid nephropathy: an update |
| title_sort | overview of aristolochic acid nephropathy an update |
| topic | aristolochic acids aristolochic acid nephropathy herbal therapy interstitial nephropathy renal tubular dysfunction |
| url | http://krcp-ksn.org/upload/pdf/j-krcp-22-211.pdf |
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