FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice

FGF21 is required for protein restriction to extend lifespan and improve metabolic health in male mice

The restriction of dietary protein or amino acid intake is well established to extend lifespan in multiple species. Here, the authors show that the endocrine hormone FGF21 is necessary for dietary protein restriction to extend lifespan and improve metabolic health in aged, male mice.

Bibliographic Details
Main Authors: Cristal M. Hill, Diana C. Albarado, Lucia G. Coco, Redin A. Spann, Md Shahjalal Khan, Emily Qualls-Creekmore, David H. Burk, Susan J. Burke, J. Jason Collier, Sangho Yu, David H. McDougal, Hans-Rudolf Berthoud, Heike Münzberg, Andrzej Bartke, Christopher D. Morrison
Format: Article
Language:English
Published: Nature Portfolio 2022-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-29499-8

Internet

https://doi.org/10.1038/s41467-022-29499-8

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