Mind the Gap: How Some Viruses Infect Their Hosts
Cryo-electron microscopy (Cryo-EM) and cryo-electron tomography (Cryo-ET) provide structural insights into complex biological processes. The podoviridae are dsDNA containing phage with short, non-contractile tails which nevertheless translocate their DNA into the cytoplasm of their host cells. Liu e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-11-01
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| Series: | Viruses |
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| Online Access: | http://www.mdpi.com/1999-4915/2/11/2536/ |
| Summary: | Cryo-electron microscopy (Cryo-EM) and cryo-electron tomography (Cryo-ET) provide structural insights into complex biological processes. The podoviridae are dsDNA containing phage with short, non-contractile tails which nevertheless translocate their DNA into the cytoplasm of their host cells. Liu et al. [1] used a combination of cryo-EM and cryo-ET to study the structural changes accompanying infection of P. marinus by the phage P-SSP7 and thereby provide unique molecular insight into the process by which the DNA transits from phage to host during infection. |
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| ISSN: | 1999-4915 |