The development and function of CD11c+ atypical B cells - insights from single cell analysis
CD11c+ T-bet+ atypical B cells (ABCs) have been identified in the context of vaccination, acute and chronic infections and autoimmune disease. However, the origins and functions of ABCs remain elusive. A major obstacle in the study of ABCs, and human MBCs more generally, has been the use of differen...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.979060/full |
| _version_ | 1798041783717855232 |
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| author | Xin Gao Ian A. Cockburn |
| author_facet | Xin Gao Ian A. Cockburn |
| author_sort | Xin Gao |
| collection | DOAJ |
| description | CD11c+ T-bet+ atypical B cells (ABCs) have been identified in the context of vaccination, acute and chronic infections and autoimmune disease. However, the origins and functions of ABCs remain elusive. A major obstacle in the study of ABCs, and human MBCs more generally, has been the use of different phenotypic markers in different contexts to identify what appear to be phenotypically similar cells. Advances in single-cell RNA sequencing (scRNA-seq) technology have allowed researchers to accurately identify ABCs in different immune contexts such as diseases and tissues. Notably, recent studies utilizing single cell techniques have demonstrated ABCs are a highly conserved memory B cell lineage. This analysis has also revealed that ABCs are more abundant in ostensibly healthy donors than previously thought. Nonetheless, the normal function of these cells remains elusive. In this review, we will focus on scRNA-seq studies to discuss recent advances in our understanding about the development and functions of ABCs. |
| first_indexed | 2024-04-11T22:26:27Z |
| format | Article |
| id | doaj.art-465526ffbc054d89a2587965bb6507aa |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T22:26:27Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-465526ffbc054d89a2587965bb6507aa2022-12-22T03:59:39ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.979060979060The development and function of CD11c+ atypical B cells - insights from single cell analysisXin GaoIan A. CockburnCD11c+ T-bet+ atypical B cells (ABCs) have been identified in the context of vaccination, acute and chronic infections and autoimmune disease. However, the origins and functions of ABCs remain elusive. A major obstacle in the study of ABCs, and human MBCs more generally, has been the use of different phenotypic markers in different contexts to identify what appear to be phenotypically similar cells. Advances in single-cell RNA sequencing (scRNA-seq) technology have allowed researchers to accurately identify ABCs in different immune contexts such as diseases and tissues. Notably, recent studies utilizing single cell techniques have demonstrated ABCs are a highly conserved memory B cell lineage. This analysis has also revealed that ABCs are more abundant in ostensibly healthy donors than previously thought. Nonetheless, the normal function of these cells remains elusive. In this review, we will focus on scRNA-seq studies to discuss recent advances in our understanding about the development and functions of ABCs.https://www.frontiersin.org/articles/10.3389/fimmu.2022.979060/fullB cellsatypical B cellsingle cell RNA seqmalariaHIVautoimmunity |
| spellingShingle | Xin Gao Ian A. Cockburn The development and function of CD11c+ atypical B cells - insights from single cell analysis Frontiers in Immunology B cells atypical B cell single cell RNA seq malaria HIV autoimmunity |
| title | The development and function of CD11c+ atypical B cells - insights from single cell analysis |
| title_full | The development and function of CD11c+ atypical B cells - insights from single cell analysis |
| title_fullStr | The development and function of CD11c+ atypical B cells - insights from single cell analysis |
| title_full_unstemmed | The development and function of CD11c+ atypical B cells - insights from single cell analysis |
| title_short | The development and function of CD11c+ atypical B cells - insights from single cell analysis |
| title_sort | development and function of cd11c atypical b cells insights from single cell analysis |
| topic | B cells atypical B cell single cell RNA seq malaria HIV autoimmunity |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.979060/full |
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