Inhibition of GSK3 Represses the Expression of Retinoic Acid Synthetic Enzyme ALDH1A2 via Wnt/β-Catenin Signaling in WiT49 Cells

Inhibition of GSK3 Represses the Expression of Retinoic Acid Synthetic Enzyme ALDH1A2 via Wnt/β-Catenin Signaling in WiT49 Cells

Organogenesis, including renal development, requires an appropriate retinoic acid concentration, which is established by differential expression of aldehyde dehydrogenase 1 family member A2 (ALDH1A2) and cytochrome P450 family 26 subfamily A/B/C member 1 (CYP26A1/B1/C1). In the fetal kidney, ALDH1A2...

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Bibliographic Details
Main Authors: Yifan Li, Hui Gong, Jiangfeng Ding, Fujuan Zhao, Jihui Du, Jun Wan, Juan Zhang, Shaoxiong Liu, Jing Li, Lei Wang, Bei Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ALDH1A2
RALDH2
fetal kidney
Wnt signaling
β-catenin
GSK3 inhibitor
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00094/full

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