Ethambutol-Induced bilateral retrobulbar neuritis with cecocentral scotoma in cervical tuberculous lymphadenitis patient: A case report with estimated plasma level consideration
Ethambutol is considered to be safest first-line antitubercular drug, and patient acceptability is rather good in both intensive and continuation phase of the tuberculosis treatment with daily regimen. The important adverse effect associated with ethambutol is optic neuritis, resulting in loss of vi...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
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| Online Access: | http://www.mjdrdypv.org/article.asp?issn=2589-8302;year=2022;volume=15;issue=6;spage=928;epage=932;aulast=Panda |
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| author | Bijoy Kumar Panda Medha Bargaje Vaibhav R Suryawanshi Sathiyanarayanan Lohidasan |
| author_facet | Bijoy Kumar Panda Medha Bargaje Vaibhav R Suryawanshi Sathiyanarayanan Lohidasan |
| author_sort | Bijoy Kumar Panda |
| collection | DOAJ |
| description | Ethambutol is considered to be safest first-line antitubercular drug, and patient acceptability is rather good in both intensive and continuation phase of the tuberculosis treatment with daily regimen. The important adverse effect associated with ethambutol is optic neuritis, resulting in loss of visual acuity, color vision, and field defects. The incidence of optic neuritis is generally directly proportional to the dose and duration of ethambutol therapy and rarely reported in a low standard dose. Here, we report a case of a 40-year-old female patient with complaints of progressive diminished vision (especially during day time) with a low daily dose (15 mg/kg/day) of ethambutol. She got diagnosed with cervical tuberculous lymphadenitis and was receiving isoniazid, rifampicin, ethambutol, and levofloxacin. In rare instances, ethambutol ocular toxicity may present with cecocentral scotoma. In rare instances, plasma levels are performed. An estimated plasma level of ethambutol was found to be in higher end (5.6 μg/ml) of the reported therapeutic range (2–6 μg/ml). Bilateral retrobulbar neuritis with cecocentral scotoma adverse effect due to ethambutol can be seen in plasma therapeutic range. |
| first_indexed | 2024-04-10T23:22:59Z |
| format | Article |
| id | doaj.art-4657ebc97a0d46a3a2a25ec39bd082b2 |
| institution | Directory Open Access Journal |
| issn | 2589-8302 2589-8310 |
| language | English |
| last_indexed | 2024-04-10T23:22:59Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Medical Journal of Dr. D.Y. Patil Vidyapeeth |
| spelling | doaj.art-4657ebc97a0d46a3a2a25ec39bd082b22023-01-12T13:28:54ZengWolters Kluwer Medknow PublicationsMedical Journal of Dr. D.Y. Patil Vidyapeeth2589-83022589-83102022-01-0115692893210.4103/mjdrdypu.mjdrdypu_231_21Ethambutol-Induced bilateral retrobulbar neuritis with cecocentral scotoma in cervical tuberculous lymphadenitis patient: A case report with estimated plasma level considerationBijoy Kumar PandaMedha BargajeVaibhav R SuryawanshiSathiyanarayanan LohidasanEthambutol is considered to be safest first-line antitubercular drug, and patient acceptability is rather good in both intensive and continuation phase of the tuberculosis treatment with daily regimen. The important adverse effect associated with ethambutol is optic neuritis, resulting in loss of visual acuity, color vision, and field defects. The incidence of optic neuritis is generally directly proportional to the dose and duration of ethambutol therapy and rarely reported in a low standard dose. Here, we report a case of a 40-year-old female patient with complaints of progressive diminished vision (especially during day time) with a low daily dose (15 mg/kg/day) of ethambutol. She got diagnosed with cervical tuberculous lymphadenitis and was receiving isoniazid, rifampicin, ethambutol, and levofloxacin. In rare instances, ethambutol ocular toxicity may present with cecocentral scotoma. In rare instances, plasma levels are performed. An estimated plasma level of ethambutol was found to be in higher end (5.6 μg/ml) of the reported therapeutic range (2–6 μg/ml). Bilateral retrobulbar neuritis with cecocentral scotoma adverse effect due to ethambutol can be seen in plasma therapeutic range.http://www.mjdrdypv.org/article.asp?issn=2589-8302;year=2022;volume=15;issue=6;spage=928;epage=932;aulast=Pandabilateral retrobulbar neuritiscecocentral scotomaethambutolplasma levels |
| spellingShingle | Bijoy Kumar Panda Medha Bargaje Vaibhav R Suryawanshi Sathiyanarayanan Lohidasan Ethambutol-Induced bilateral retrobulbar neuritis with cecocentral scotoma in cervical tuberculous lymphadenitis patient: A case report with estimated plasma level consideration Medical Journal of Dr. D.Y. Patil Vidyapeeth bilateral retrobulbar neuritis cecocentral scotoma ethambutol plasma levels |
| title | Ethambutol-Induced bilateral retrobulbar neuritis with cecocentral scotoma in cervical tuberculous lymphadenitis patient: A case report with estimated plasma level consideration |
| title_full | Ethambutol-Induced bilateral retrobulbar neuritis with cecocentral scotoma in cervical tuberculous lymphadenitis patient: A case report with estimated plasma level consideration |
| title_fullStr | Ethambutol-Induced bilateral retrobulbar neuritis with cecocentral scotoma in cervical tuberculous lymphadenitis patient: A case report with estimated plasma level consideration |
| title_full_unstemmed | Ethambutol-Induced bilateral retrobulbar neuritis with cecocentral scotoma in cervical tuberculous lymphadenitis patient: A case report with estimated plasma level consideration |
| title_short | Ethambutol-Induced bilateral retrobulbar neuritis with cecocentral scotoma in cervical tuberculous lymphadenitis patient: A case report with estimated plasma level consideration |
| title_sort | ethambutol induced bilateral retrobulbar neuritis with cecocentral scotoma in cervical tuberculous lymphadenitis patient a case report with estimated plasma level consideration |
| topic | bilateral retrobulbar neuritis cecocentral scotoma ethambutol plasma levels |
| url | http://www.mjdrdypv.org/article.asp?issn=2589-8302;year=2022;volume=15;issue=6;spage=928;epage=932;aulast=Panda |
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