Acid base and metabolic parameters of the umbilical cord blood and cerebral oxygenation immediately after birth
ObjectiveAim was to investigate whether acid-base and metabolic parameters obtained from arterial umbilical cord blood affect cerebral oxygenation after birth in preterm neonates with respiratory support and in term neonates without respiratory support.Study designThis was a post-hoc analysis of sec...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2024.1385726/full |
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| author | Martin Dusleag Martin Dusleag Berndt Urlesberger Berndt Urlesberger Bernhard Schwaberger Bernhard Schwaberger Nariae Baik-Schneditz Nariae Baik-Schneditz Christoph Schlatzer Christoph Schlatzer Christina H. Wolfsberger Christina H. Wolfsberger Gerhard Pichler Gerhard Pichler |
| author_facet | Martin Dusleag Martin Dusleag Berndt Urlesberger Berndt Urlesberger Bernhard Schwaberger Bernhard Schwaberger Nariae Baik-Schneditz Nariae Baik-Schneditz Christoph Schlatzer Christoph Schlatzer Christina H. Wolfsberger Christina H. Wolfsberger Gerhard Pichler Gerhard Pichler |
| author_sort | Martin Dusleag |
| collection | DOAJ |
| description | ObjectiveAim was to investigate whether acid-base and metabolic parameters obtained from arterial umbilical cord blood affect cerebral oxygenation after birth in preterm neonates with respiratory support and in term neonates without respiratory support.Study designThis was a post-hoc analysis of secondary outcome parameters of a prospective observational study including preterm neonates with and term neonates without respiratory support. Non-asphyxiated neonates with cerebral oxygenation measured with near-infrared spectroscopy during the first 15 min and with blood gas analyses from arterial umbilical cord blood were included. Arterial oxygen saturation (SpO2) and heart rate (HR) were monitored with pulse oximetry. Potential correlations were investigated between acid-base and metabolic parameters (pH-value, bicarbonate, base-excess, and lactate) and crSO2/cFTOE 5 min after birth.ResultsSeventy-seven neonates were included: 14 preterm neonates with respiratory support (mean gestational age [GA] 31.4 ± 4.1 weeks; mean birth weight [BW] 1,690 ± 640 g) and 63 term neonates without respiratory support (GA 38.7 ± 0.8 weeks; BW 3,258 ± 443 g). Mean crSO2 5 min after birth was 44.0% ± 24.2% in preterm and 62.2% ± 20.01% in term neonates. Mean cFTOE 5 min after birth was 0.46 ± 0.06 in preterm and 0.27 ± 0.19 in term neonates. In preterm neonates with respiratory support higher lactate was significantly associated with lower crSO2 and SpO2 and tended to be associated with higher cFTOE. In term neonates without respiratory support no significant correlations were found.ConclusionIn non-asphyxiated preterm neonates with respiratory support, lactate levels were negatively associated with crSO2 and SpO2, whereas in term neonates without respiratory support no associations were observed. |
| first_indexed | 2024-04-24T17:35:56Z |
| format | Article |
| id | doaj.art-4658ec9484094729a6d859ef3a5e4771 |
| institution | Directory Open Access Journal |
| issn | 2296-2360 |
| language | English |
| last_indexed | 2024-04-24T17:35:56Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj.art-4658ec9484094729a6d859ef3a5e47712024-03-28T04:56:07ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602024-03-011210.3389/fped.2024.13857261385726Acid base and metabolic parameters of the umbilical cord blood and cerebral oxygenation immediately after birthMartin Dusleag0Martin Dusleag1Berndt Urlesberger2Berndt Urlesberger3Bernhard Schwaberger4Bernhard Schwaberger5Nariae Baik-Schneditz6Nariae Baik-Schneditz7Christoph Schlatzer8Christoph Schlatzer9Christina H. Wolfsberger10Christina H. Wolfsberger11Gerhard Pichler12Gerhard Pichler13Division of Neonatology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, AustriaResearch Unit for Neonatal Micro- and Macrocirculation, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, AustriaDivision of Neonatology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, AustriaResearch Unit for Neonatal Micro- and Macrocirculation, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, AustriaDivision of Neonatology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, AustriaResearch Unit for Neonatal Micro- and Macrocirculation, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, AustriaDivision of Neonatology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, AustriaResearch Unit for Neonatal Micro- and Macrocirculation, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, AustriaDivision of Neonatology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, AustriaResearch Unit for Neonatal Micro- and Macrocirculation, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, AustriaDivision of Neonatology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, AustriaResearch Unit for Neonatal Micro- and Macrocirculation, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, AustriaDivision of Neonatology, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, AustriaResearch Unit for Neonatal Micro- and Macrocirculation, Department of Paediatrics and Adolescent Medicine, Medical University of Graz, Graz, AustriaObjectiveAim was to investigate whether acid-base and metabolic parameters obtained from arterial umbilical cord blood affect cerebral oxygenation after birth in preterm neonates with respiratory support and in term neonates without respiratory support.Study designThis was a post-hoc analysis of secondary outcome parameters of a prospective observational study including preterm neonates with and term neonates without respiratory support. Non-asphyxiated neonates with cerebral oxygenation measured with near-infrared spectroscopy during the first 15 min and with blood gas analyses from arterial umbilical cord blood were included. Arterial oxygen saturation (SpO2) and heart rate (HR) were monitored with pulse oximetry. Potential correlations were investigated between acid-base and metabolic parameters (pH-value, bicarbonate, base-excess, and lactate) and crSO2/cFTOE 5 min after birth.ResultsSeventy-seven neonates were included: 14 preterm neonates with respiratory support (mean gestational age [GA] 31.4 ± 4.1 weeks; mean birth weight [BW] 1,690 ± 640 g) and 63 term neonates without respiratory support (GA 38.7 ± 0.8 weeks; BW 3,258 ± 443 g). Mean crSO2 5 min after birth was 44.0% ± 24.2% in preterm and 62.2% ± 20.01% in term neonates. Mean cFTOE 5 min after birth was 0.46 ± 0.06 in preterm and 0.27 ± 0.19 in term neonates. In preterm neonates with respiratory support higher lactate was significantly associated with lower crSO2 and SpO2 and tended to be associated with higher cFTOE. In term neonates without respiratory support no significant correlations were found.ConclusionIn non-asphyxiated preterm neonates with respiratory support, lactate levels were negatively associated with crSO2 and SpO2, whereas in term neonates without respiratory support no associations were observed.https://www.frontiersin.org/articles/10.3389/fped.2024.1385726/fullneonatesacid-base and metabolic parameterscerebral oxygenationimmediate neonatal transitionnear-infrared spectroscopy |
| spellingShingle | Martin Dusleag Martin Dusleag Berndt Urlesberger Berndt Urlesberger Bernhard Schwaberger Bernhard Schwaberger Nariae Baik-Schneditz Nariae Baik-Schneditz Christoph Schlatzer Christoph Schlatzer Christina H. Wolfsberger Christina H. Wolfsberger Gerhard Pichler Gerhard Pichler Acid base and metabolic parameters of the umbilical cord blood and cerebral oxygenation immediately after birth Frontiers in Pediatrics neonates acid-base and metabolic parameters cerebral oxygenation immediate neonatal transition near-infrared spectroscopy |
| title | Acid base and metabolic parameters of the umbilical cord blood and cerebral oxygenation immediately after birth |
| title_full | Acid base and metabolic parameters of the umbilical cord blood and cerebral oxygenation immediately after birth |
| title_fullStr | Acid base and metabolic parameters of the umbilical cord blood and cerebral oxygenation immediately after birth |
| title_full_unstemmed | Acid base and metabolic parameters of the umbilical cord blood and cerebral oxygenation immediately after birth |
| title_short | Acid base and metabolic parameters of the umbilical cord blood and cerebral oxygenation immediately after birth |
| title_sort | acid base and metabolic parameters of the umbilical cord blood and cerebral oxygenation immediately after birth |
| topic | neonates acid-base and metabolic parameters cerebral oxygenation immediate neonatal transition near-infrared spectroscopy |
| url | https://www.frontiersin.org/articles/10.3389/fped.2024.1385726/full |
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