The complications of tramadol and methadone use to women’s sexual hormone
Background and aims: Tramadol and methadone are synthetic opioid drugs that are widely used in various fields of medicine. This review article was performed to investigate the hormone disturbance of long-term tramadol and methadone use in women. Methods: Keywords were determined using the MeSH brows...
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| Format: | Article |
| Language: | English |
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Shahrekord University of Medical Sciences
2023-05-01
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| Series: | Journal of Shahrekord University of Medical Sciences |
| Subjects: | |
| Online Access: | https://j.skums.ac.ir/PDF/jskums-25-143.pdf |
| _version_ | 1827862047530942464 |
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| author | Khadijeh Saravani Pantea Ramezannezhad Mohaddese Delpisheh Batool Shahraki Mojahed Omid Bameri Halimeh Aali |
| author_facet | Khadijeh Saravani Pantea Ramezannezhad Mohaddese Delpisheh Batool Shahraki Mojahed Omid Bameri Halimeh Aali |
| author_sort | Khadijeh Saravani |
| collection | DOAJ |
| description | Background and aims: Tramadol and methadone are synthetic opioid drugs that are widely used in various fields of medicine. This review article was performed to investigate the hormone disturbance of long-term tramadol and methadone use in women. Methods: Keywords were determined using the MeSH browser and then searched in ISI, Scopus, EMBASE, and PubMed databases on 25.5.2022. The articles with non-English language, articles whose full text was not retrieved, and studies that were irrelevant to the aim of this study were excluded from the investigation. Results: Methadone and tramadol affected a sexual hormone in women through an impact on the hypothalamic-pituitary-gonadal axis. They could reduce the levels of follicle stimulating hormone and luteinizing hormone, increase prolactin production, and finally, reduce gonadal steroids. Opioids also could influence thyroid and adrenal glands and subsequently increase thyroid-stimulating hormone, and reduce dehydroepiandrosterone. Eventually, this mechanism caused a disturbance in sexual hormone disturbance in women. Conclusion: Overall, long-term methadone and tramadol consumption as opioid substances could cause sexual hormone disturbance in women. |
| first_indexed | 2024-03-12T13:47:54Z |
| format | Article |
| id | doaj.art-465a7bfb22a740b9b4feed6ddaa93887 |
| institution | Directory Open Access Journal |
| issn | 2717-0071 |
| language | English |
| last_indexed | 2024-03-12T13:47:54Z |
| publishDate | 2023-05-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Journal of Shahrekord University of Medical Sciences |
| spelling | doaj.art-465a7bfb22a740b9b4feed6ddaa938872023-08-23T08:08:55ZengShahrekord University of Medical SciencesJournal of Shahrekord University of Medical Sciences2717-00712023-05-0125314314810.34172/jsums.2023.752jskums-752The complications of tramadol and methadone use to women’s sexual hormoneKhadijeh Saravani0Pantea Ramezannezhad1Mohaddese Delpisheh2Batool Shahraki Mojahed3Omid Bameri4Halimeh Aali5Assistant Professor of Forensic Medicine and Toxicology, Zabol University of Medical Sciences, Zabol, IranDepartment of Forensic Medicine and Toxicology, Faculty of Medicine, Shahrekord University of Medical Sciences, Shahrekord, IranDepartment of Nursing and Midwifery, Zabol University of Medical Sciences, Zabol, IranDepartment of Obstetrics and Gynecology, Zabol University of Medical Sciences, Zabol, IranAssistant Professor of Emergency Medicine, Zabol University of Medical Sciences, Zabol, IranAssistant Professor of Internal Medicine, Department of Internal Medicine, Zabol University of Medical Sciences, Zabol, IranBackground and aims: Tramadol and methadone are synthetic opioid drugs that are widely used in various fields of medicine. This review article was performed to investigate the hormone disturbance of long-term tramadol and methadone use in women. Methods: Keywords were determined using the MeSH browser and then searched in ISI, Scopus, EMBASE, and PubMed databases on 25.5.2022. The articles with non-English language, articles whose full text was not retrieved, and studies that were irrelevant to the aim of this study were excluded from the investigation. Results: Methadone and tramadol affected a sexual hormone in women through an impact on the hypothalamic-pituitary-gonadal axis. They could reduce the levels of follicle stimulating hormone and luteinizing hormone, increase prolactin production, and finally, reduce gonadal steroids. Opioids also could influence thyroid and adrenal glands and subsequently increase thyroid-stimulating hormone, and reduce dehydroepiandrosterone. Eventually, this mechanism caused a disturbance in sexual hormone disturbance in women. Conclusion: Overall, long-term methadone and tramadol consumption as opioid substances could cause sexual hormone disturbance in women.https://j.skums.ac.ir/PDF/jskums-25-143.pdfmethadonetramadolsexualsex hormonewomen |
| spellingShingle | Khadijeh Saravani Pantea Ramezannezhad Mohaddese Delpisheh Batool Shahraki Mojahed Omid Bameri Halimeh Aali The complications of tramadol and methadone use to women’s sexual hormone Journal of Shahrekord University of Medical Sciences methadone tramadol sexual sex hormone women |
| title | The complications of tramadol and methadone use to women’s sexual hormone |
| title_full | The complications of tramadol and methadone use to women’s sexual hormone |
| title_fullStr | The complications of tramadol and methadone use to women’s sexual hormone |
| title_full_unstemmed | The complications of tramadol and methadone use to women’s sexual hormone |
| title_short | The complications of tramadol and methadone use to women’s sexual hormone |
| title_sort | complications of tramadol and methadone use to women s sexual hormone |
| topic | methadone tramadol sexual sex hormone women |
| url | https://j.skums.ac.ir/PDF/jskums-25-143.pdf |
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