Pathogenesis and Virulence of <i>Candida albicans</i> and <i>Candida glabrata</i>
Fungal infections in humans have historically received comparatively less attention than those caused by bacteria and viruses. This may, in part, stem from the relative differences in infection prevalence. However, the more widespread use of immunosuppressive therapy, invasive surgery and medical de...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Pathogens |
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| Online Access: | https://www.mdpi.com/2076-0817/9/9/752 |
| _version_ | 1797553574832504832 |
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| author | Mariana Henriques David Williams |
| author_facet | Mariana Henriques David Williams |
| author_sort | Mariana Henriques |
| collection | DOAJ |
| description | Fungal infections in humans have historically received comparatively less attention than those caused by bacteria and viruses. This may, in part, stem from the relative differences in infection prevalence. However, the more widespread use of immunosuppressive therapy, invasive surgery and medical devices in modern medicine has resulted in a more frequent occurrence of human fungal infection. There are a number of fungi that can cause human disease. However, it is arguably a species of the genus <i>Candida</i> that are most often encountered. There are over 150 <i>Candida</i> species that are widely encountered in the environment and in animal hosts, however, only a small number are opportunistic pathogens of humans. <i>Candida albicans</i> is a polymorphic yeast-like fungus and undoubtedly the species most often recovered from human infection. As such, the virulence of <i>C. albicans</i> and its susceptibility to antifungal agents are often investigated. More recently, the prevalence of infections caused by non-<i>C. albicans</i><i>Candida</i> species have increased and, amongst these, infections caused by <i>Candida glabrata</i> have received attention given its often-higher tolerance to frequently used antifungals exhibited by this species. The papers presented in this Special Issue have focused on aspects relating to host responses to <i>Candida</i> infection, the efficacy of novel therapeutic agents and also treatment regimes. The papers highlight novel findings in their respective areas, whilst also highlighting the need for further research in these key and largely under-researched areas of candidoses. |
| first_indexed | 2024-03-10T16:18:27Z |
| format | Article |
| id | doaj.art-465a8f88d7b94287ac511f08aa535f20 |
| institution | Directory Open Access Journal |
| issn | 2076-0817 |
| language | English |
| last_indexed | 2024-03-10T16:18:27Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj.art-465a8f88d7b94287ac511f08aa535f202023-11-20T13:51:33ZengMDPI AGPathogens2076-08172020-09-019975210.3390/pathogens9090752Pathogenesis and Virulence of <i>Candida albicans</i> and <i>Candida glabrata</i>Mariana Henriques0David Williams1Department of Biological Engineering, University of Minho, 4715-338 Braga, PortugalOral and Biomedical Sciences, School of Dentistry, College of Biomedical and Life Sciences, Cardiff University, Heath Park, Cardiff CF14 4XY, UKFungal infections in humans have historically received comparatively less attention than those caused by bacteria and viruses. This may, in part, stem from the relative differences in infection prevalence. However, the more widespread use of immunosuppressive therapy, invasive surgery and medical devices in modern medicine has resulted in a more frequent occurrence of human fungal infection. There are a number of fungi that can cause human disease. However, it is arguably a species of the genus <i>Candida</i> that are most often encountered. There are over 150 <i>Candida</i> species that are widely encountered in the environment and in animal hosts, however, only a small number are opportunistic pathogens of humans. <i>Candida albicans</i> is a polymorphic yeast-like fungus and undoubtedly the species most often recovered from human infection. As such, the virulence of <i>C. albicans</i> and its susceptibility to antifungal agents are often investigated. More recently, the prevalence of infections caused by non-<i>C. albicans</i><i>Candida</i> species have increased and, amongst these, infections caused by <i>Candida glabrata</i> have received attention given its often-higher tolerance to frequently used antifungals exhibited by this species. The papers presented in this Special Issue have focused on aspects relating to host responses to <i>Candida</i> infection, the efficacy of novel therapeutic agents and also treatment regimes. The papers highlight novel findings in their respective areas, whilst also highlighting the need for further research in these key and largely under-researched areas of candidoses.https://www.mdpi.com/2076-0817/9/9/752<i>Candida albicans</i><i>Candida glabrata</i><i>Candida</i> infectionvirulence factorspathogenicity |
| spellingShingle | Mariana Henriques David Williams Pathogenesis and Virulence of <i>Candida albicans</i> and <i>Candida glabrata</i> Pathogens <i>Candida albicans</i> <i>Candida glabrata</i> <i>Candida</i> infection virulence factors pathogenicity |
| title | Pathogenesis and Virulence of <i>Candida albicans</i> and <i>Candida glabrata</i> |
| title_full | Pathogenesis and Virulence of <i>Candida albicans</i> and <i>Candida glabrata</i> |
| title_fullStr | Pathogenesis and Virulence of <i>Candida albicans</i> and <i>Candida glabrata</i> |
| title_full_unstemmed | Pathogenesis and Virulence of <i>Candida albicans</i> and <i>Candida glabrata</i> |
| title_short | Pathogenesis and Virulence of <i>Candida albicans</i> and <i>Candida glabrata</i> |
| title_sort | pathogenesis and virulence of i candida albicans i and i candida glabrata i |
| topic | <i>Candida albicans</i> <i>Candida glabrata</i> <i>Candida</i> infection virulence factors pathogenicity |
| url | https://www.mdpi.com/2076-0817/9/9/752 |
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