The Role of Catestatin in Preeclampsia
Preeclampsia (PE) is a unique pregnancy disorder affecting women across the world. It is characterized by the new onset of hypertension with coexisting end-organ damage. Although the disease has been known for centuries, its exact pathophysiology and, most importantly, its prevention remain elusive....
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/25/5/2461 |
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| author | Michalina Bralewska Tadeusz Pietrucha Agata Sakowicz |
| author_facet | Michalina Bralewska Tadeusz Pietrucha Agata Sakowicz |
| author_sort | Michalina Bralewska |
| collection | DOAJ |
| description | Preeclampsia (PE) is a unique pregnancy disorder affecting women across the world. It is characterized by the new onset of hypertension with coexisting end-organ damage. Although the disease has been known for centuries, its exact pathophysiology and, most importantly, its prevention remain elusive. The basis of its associated molecular changes has been attributed to the placenta and the hormones regulating its function. One such hormone is chromogranin A (CgA). In the placenta, CgA is cleaved to form a variety of biologically active peptides, including catestatin (CST), known inter alia for its vasodilatory effects. Recent studies indicate that the CST protein level is diminished both in patients with hypertension and those with PE. Therefore, the aim of the present paper is to review the most recent and most relevant in vitro, in vivo, and clinical studies to provide an overview of the proposed impact of CST on the molecular processes of PE and to consider the possibilities for future experiments in this area. |
| first_indexed | 2024-04-25T00:29:56Z |
| format | Article |
| id | doaj.art-465c2380c0394950a1170f45c0520f23 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-04-25T00:29:56Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-465c2380c0394950a1170f45c0520f232024-03-12T16:45:04ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672024-02-01255246110.3390/ijms25052461The Role of Catestatin in PreeclampsiaMichalina Bralewska0Tadeusz Pietrucha1Agata Sakowicz2Department of Medical Biotechnology, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, PolandDepartment of Medical Biotechnology, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, PolandDepartment of Medical Biotechnology, Medical University of Lodz, Zeligowskiego 7/9, 90-752 Lodz, PolandPreeclampsia (PE) is a unique pregnancy disorder affecting women across the world. It is characterized by the new onset of hypertension with coexisting end-organ damage. Although the disease has been known for centuries, its exact pathophysiology and, most importantly, its prevention remain elusive. The basis of its associated molecular changes has been attributed to the placenta and the hormones regulating its function. One such hormone is chromogranin A (CgA). In the placenta, CgA is cleaved to form a variety of biologically active peptides, including catestatin (CST), known inter alia for its vasodilatory effects. Recent studies indicate that the CST protein level is diminished both in patients with hypertension and those with PE. Therefore, the aim of the present paper is to review the most recent and most relevant in vitro, in vivo, and clinical studies to provide an overview of the proposed impact of CST on the molecular processes of PE and to consider the possibilities for future experiments in this area.https://www.mdpi.com/1422-0067/25/5/2461catestatinpreeclampsiapregnancychromogranin A |
| spellingShingle | Michalina Bralewska Tadeusz Pietrucha Agata Sakowicz The Role of Catestatin in Preeclampsia International Journal of Molecular Sciences catestatin preeclampsia pregnancy chromogranin A |
| title | The Role of Catestatin in Preeclampsia |
| title_full | The Role of Catestatin in Preeclampsia |
| title_fullStr | The Role of Catestatin in Preeclampsia |
| title_full_unstemmed | The Role of Catestatin in Preeclampsia |
| title_short | The Role of Catestatin in Preeclampsia |
| title_sort | role of catestatin in preeclampsia |
| topic | catestatin preeclampsia pregnancy chromogranin A |
| url | https://www.mdpi.com/1422-0067/25/5/2461 |
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