Piperacillin-Tazobactam (TZP) Resistance in Escherichia coli Due to Hyperproduction of TEM-1 β-Lactamase Mediated by the Promoter Pa/Pb

Piperacillin-Tazobactam (TZP) Resistance in Escherichia coli Due to Hyperproduction of TEM-1 β-Lactamase Mediated by the Promoter Pa/Pb

TEM-1, mediated by plasmid and transposon, is the most commonly encountered β-lactamase in Gram-negative bacteria. Four different promoters upstream of blaTEM-related genes have been identified: the weak P3 promoter, and the strong promoters Pa/Pb, P4, and P5. In this study, we investigated the gene...

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Bibliographic Details
Main Authors: Kaixin Zhou, Ying Tao, Lizhong Han, Yuxing Ni, Jingyong Sun
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Microbiology
Subjects:
TZP resistance
Escherichia coli
Pa/Pb
β-lactamase
antimicobial
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00833/full

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