The anti-inflammatory and antioxidant effects of Rosa damascena Mill. essential oil on the lung injury in the CLP model
Background: Sepsis or infection is the second leading cause of death in people who are intensive care units. Due to the side effects of NSAIDs drugs, the use of medicinal plants with anti-inflammatory such as Rosa (R.) damascene Mill. for treating and reducing the symptoms of the inflammation has be...
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| Format: | Article |
| Language: | English |
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Institue of Medicinal Plants, ACECR
2020-06-01
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| Series: | Journal of Medicinal Plants |
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| Online Access: | http://jmp.ir/article-1-2402-en.html |
| _version_ | 1818647077237817344 |
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| author | Abolfazl Dadkhah Faezeh Fatemi Mohammad Reza Mohammadi Malayeri Mohammad Hassan Karvin Ashtiani Zahra Mosavi Sabere Naij Salome Dini |
| author_facet | Abolfazl Dadkhah Faezeh Fatemi Mohammad Reza Mohammadi Malayeri Mohammad Hassan Karvin Ashtiani Zahra Mosavi Sabere Naij Salome Dini |
| author_sort | Abolfazl Dadkhah |
| collection | DOAJ |
| description | Background: Sepsis or infection is the second leading cause of death in people who are intensive care units. Due to the side effects of NSAIDs drugs, the use of medicinal plants with anti-inflammatory such as Rosa (R.) damascene Mill. for treating and reducing the symptoms of the inflammation has been suggested. Objective: The current study aimed to evaluate the anti-inflammatory and antioxodant activities of Rosa (R.) damascena Mill. essential oils in the lung tissue of the septic rats induced by the experimental cecal ligation and puncture (CLP) rat model. Methods: The rats were divided into 5 groups: negative control group, positive control group and treatment groups with R. damascena Mill. essential oils and indomethacin. After 24h of CLP surgery, the oxidative parameters were measured. Results: The induction of sepsis reduced the levels of glutathione (GSH), ferric reducing antioxidant power (FRAP) as well as increased the levels lipid peroxidation (LP), myeloperoxidase (MPO), prostaglandin E2 (PGE2) and cyclooxygenase-2 (COX-2), but it had no effects on glutathione S-transferase (GST). However, the treatments of rats with R. damascena Mill. essential oils have diminished the levels of biochemical parameters. Histopathological studies also demonstrated that the induction of sepsis resulted in the lung tissue damages, while these were improved by the treatment of rats with R. damascena Mill. essential oils. Conclusion: The oxidative damages of the lung tissue were induced by the sepsis and the administartionof R. damascena Mill. essential oils can be effecient in the prevention and improvement of the injuries. |
| first_indexed | 2024-12-17T00:56:48Z |
| format | Article |
| id | doaj.art-46629acd891949208c8bdc5441c9a978 |
| institution | Directory Open Access Journal |
| issn | 2717-204X 2717-2058 |
| language | English |
| last_indexed | 2024-12-17T00:56:48Z |
| publishDate | 2020-06-01 |
| publisher | Institue of Medicinal Plants, ACECR |
| record_format | Article |
| series | Journal of Medicinal Plants |
| spelling | doaj.art-46629acd891949208c8bdc5441c9a9782022-12-21T22:09:35ZengInstitue of Medicinal Plants, ACECRJournal of Medicinal Plants2717-204X2717-20582020-06-011974277294The anti-inflammatory and antioxidant effects of Rosa damascena Mill. essential oil on the lung injury in the CLP modelAbolfazl Dadkhah0Faezeh Fatemi1Mohammad Reza Mohammadi Malayeri2Mohammad Hassan Karvin Ashtiani3Zahra Mosavi4Sabere Naij5Salome Dini6 Department of Medicine, Faculty of Medicine, Qom Branch, Islamic Azad University, Qom, Iran Materials and Nuclear Fuel Research School, Nuclear Science and Technology Research Institute, Tehran, Iran Department of Pathobiology, Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran Department of biology, Faculty of Sciences, Hakim Sabzevari University, Sabzevar, Iran Department of Biochemistry, Faculty of Sciences, Payame-e-Noor University, Tehran, Iran Faculty of Botany, Payam Noor University, Tehran, Iran Young Researchers and Elite Club, Karaj Branch, Islamic Azad University, Karaj, Iran Background: Sepsis or infection is the second leading cause of death in people who are intensive care units. Due to the side effects of NSAIDs drugs, the use of medicinal plants with anti-inflammatory such as Rosa (R.) damascene Mill. for treating and reducing the symptoms of the inflammation has been suggested. Objective: The current study aimed to evaluate the anti-inflammatory and antioxodant activities of Rosa (R.) damascena Mill. essential oils in the lung tissue of the septic rats induced by the experimental cecal ligation and puncture (CLP) rat model. Methods: The rats were divided into 5 groups: negative control group, positive control group and treatment groups with R. damascena Mill. essential oils and indomethacin. After 24h of CLP surgery, the oxidative parameters were measured. Results: The induction of sepsis reduced the levels of glutathione (GSH), ferric reducing antioxidant power (FRAP) as well as increased the levels lipid peroxidation (LP), myeloperoxidase (MPO), prostaglandin E2 (PGE2) and cyclooxygenase-2 (COX-2), but it had no effects on glutathione S-transferase (GST). However, the treatments of rats with R. damascena Mill. essential oils have diminished the levels of biochemical parameters. Histopathological studies also demonstrated that the induction of sepsis resulted in the lung tissue damages, while these were improved by the treatment of rats with R. damascena Mill. essential oils. Conclusion: The oxidative damages of the lung tissue were induced by the sepsis and the administartionof R. damascena Mill. essential oils can be effecient in the prevention and improvement of the injuries.http://jmp.ir/article-1-2402-en.html<i>rosa damascene</i> mill. essential oilsclpoxidative stresssepsislung tissue |
| spellingShingle | Abolfazl Dadkhah Faezeh Fatemi Mohammad Reza Mohammadi Malayeri Mohammad Hassan Karvin Ashtiani Zahra Mosavi Sabere Naij Salome Dini The anti-inflammatory and antioxidant effects of Rosa damascena Mill. essential oil on the lung injury in the CLP model Journal of Medicinal Plants <i>rosa damascene</i> mill. essential oils clp oxidative stress sepsis lung tissue |
| title | The anti-inflammatory and antioxidant effects of Rosa damascena Mill. essential oil on the lung injury in the CLP model |
| title_full | The anti-inflammatory and antioxidant effects of Rosa damascena Mill. essential oil on the lung injury in the CLP model |
| title_fullStr | The anti-inflammatory and antioxidant effects of Rosa damascena Mill. essential oil on the lung injury in the CLP model |
| title_full_unstemmed | The anti-inflammatory and antioxidant effects of Rosa damascena Mill. essential oil on the lung injury in the CLP model |
| title_short | The anti-inflammatory and antioxidant effects of Rosa damascena Mill. essential oil on the lung injury in the CLP model |
| title_sort | anti inflammatory and antioxidant effects of rosa damascena mill essential oil on the lung injury in the clp model |
| topic | <i>rosa damascene</i> mill. essential oils clp oxidative stress sepsis lung tissue |
| url | http://jmp.ir/article-1-2402-en.html |
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