Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation

Histone deacetylase 3 represses cholesterol efflux during CD4+ T-cell activation

After antigenic activation, quiescent naive CD4+ T cells alter their metabolism to proliferate. This metabolic shift increases production of nucleotides, amino acids, fatty acids, and sterols. Here, we show that histone deacetylase 3 (HDAC3) is critical for activation of murine peripheral CD4+ T cel...

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Bibliographic Details
Main Authors: Drew Wilfahrt, Rachael L Philips, Jyoti Lama, Monika Kizerwetter, Michael Jeremy Shapiro, Shaylene A McCue, Madeleine M Kennedy, Matthew J Rajcula, Hu Zeng, Virginia Smith Shapiro
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-12-01
Series:eLife
Subjects:
HDAC3
T cell activation
cholesterol regulation
Online Access:https://elifesciences.org/articles/70978

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