Shifts in the selectivity filter dynamics cause modal gating in K+ channels
Spontaneous activity shifts at constant experimental conditions are widespread among ion channels but the molecular origins are poorly understood. Here, using solid-state NMR and MD simulations, the authors reveal that modal gating shifts in K + channels are caused by large shifts in the channel dyn...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-01-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-07973-6 |
| _version_ | 1819035767891034112 |
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| author | Shehrazade Jekhmane João Medeiros-Silva Jing Li Felix Kümmerer Christoph Müller-Hermes Marc Baldus Benoît Roux Markus Weingarth |
| author_facet | Shehrazade Jekhmane João Medeiros-Silva Jing Li Felix Kümmerer Christoph Müller-Hermes Marc Baldus Benoît Roux Markus Weingarth |
| author_sort | Shehrazade Jekhmane |
| collection | DOAJ |
| description | Spontaneous activity shifts at constant experimental conditions are widespread among ion channels but the molecular origins are poorly understood. Here, using solid-state NMR and MD simulations, the authors reveal that modal gating shifts in K + channels are caused by large shifts in the channel dynamics which perturb the selectivity filter. |
| first_indexed | 2024-12-21T07:54:52Z |
| format | Article |
| id | doaj.art-4666bccf84aa4230955d529c44e30403 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T07:54:52Z |
| publishDate | 2019-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4666bccf84aa4230955d529c44e304032022-12-21T19:10:59ZengNature PortfolioNature Communications2041-17232019-01-0110111210.1038/s41467-018-07973-6Shifts in the selectivity filter dynamics cause modal gating in K+ channelsShehrazade Jekhmane0João Medeiros-Silva1Jing Li2Felix Kümmerer3Christoph Müller-Hermes4Marc Baldus5Benoît Roux6Markus Weingarth7NMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht UniversityNMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht UniversityDepartment of Biochemistry and Molecular Biology, The University of ChicagoNMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht UniversityNMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht UniversityNMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht UniversityDepartment of Biochemistry and Molecular Biology, The University of ChicagoNMR Spectroscopy, Bijvoet Center for Biomolecular Research, Department of Chemistry, Faculty of Science, Utrecht UniversitySpontaneous activity shifts at constant experimental conditions are widespread among ion channels but the molecular origins are poorly understood. Here, using solid-state NMR and MD simulations, the authors reveal that modal gating shifts in K + channels are caused by large shifts in the channel dynamics which perturb the selectivity filter.https://doi.org/10.1038/s41467-018-07973-6 |
| spellingShingle | Shehrazade Jekhmane João Medeiros-Silva Jing Li Felix Kümmerer Christoph Müller-Hermes Marc Baldus Benoît Roux Markus Weingarth Shifts in the selectivity filter dynamics cause modal gating in K+ channels Nature Communications |
| title | Shifts in the selectivity filter dynamics cause modal gating in K+ channels |
| title_full | Shifts in the selectivity filter dynamics cause modal gating in K+ channels |
| title_fullStr | Shifts in the selectivity filter dynamics cause modal gating in K+ channels |
| title_full_unstemmed | Shifts in the selectivity filter dynamics cause modal gating in K+ channels |
| title_short | Shifts in the selectivity filter dynamics cause modal gating in K+ channels |
| title_sort | shifts in the selectivity filter dynamics cause modal gating in k channels |
| url | https://doi.org/10.1038/s41467-018-07973-6 |
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