Functional circuits of new neurons in the dentate gyrus
The hippocampus is crucial for memory formation. New neurons are added throughout life to the hippocampal dentate gyrus (DG), a brain area considered important for differential storage of similar experiences and contexts. To better understand the functional contribution of adult neurogenesis to patt...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-02-01
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| Series: | Frontiers in Neural Circuits |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00015/full |
| _version_ | 1811298070861709312 |
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| author | Carmen eVivar Henriette eVan Praag |
| author_facet | Carmen eVivar Henriette eVan Praag |
| author_sort | Carmen eVivar |
| collection | DOAJ |
| description | The hippocampus is crucial for memory formation. New neurons are added throughout life to the hippocampal dentate gyrus (DG), a brain area considered important for differential storage of similar experiences and contexts. To better understand the functional contribution of adult neurogenesis to pattern separation processes, we recently used a novel synapse specific trans-neuronal tracing approach to identify the (sub) cortical inputs to new dentate granule cells. It was observed that newly born neurons receive sequential innervation from structures important for memory function. Initially, septal-hippocampal cells provide input to new neurons, followed after about one month by perirhinal and lateral entorhinal cortex. These cortical areas are deemed relevant to encoding of novel environmental information and may enable pattern separation. Here, we review the developmental time-course and proposed functional relevance of new neurons, within the context of their unique neural circuitry. |
| first_indexed | 2024-04-13T06:14:20Z |
| format | Article |
| id | doaj.art-4667b70279824c05b6dbaace756b0bd3 |
| institution | Directory Open Access Journal |
| issn | 1662-5110 |
| language | English |
| last_indexed | 2024-04-13T06:14:20Z |
| publishDate | 2013-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neural Circuits |
| spelling | doaj.art-4667b70279824c05b6dbaace756b0bd32022-12-22T02:58:53ZengFrontiers Media S.A.Frontiers in Neural Circuits1662-51102013-02-01710.3389/fncir.2013.0001538554Functional circuits of new neurons in the dentate gyrusCarmen eVivar0Henriette eVan Praag1National Institutes of HealthNational Institutes of HealthThe hippocampus is crucial for memory formation. New neurons are added throughout life to the hippocampal dentate gyrus (DG), a brain area considered important for differential storage of similar experiences and contexts. To better understand the functional contribution of adult neurogenesis to pattern separation processes, we recently used a novel synapse specific trans-neuronal tracing approach to identify the (sub) cortical inputs to new dentate granule cells. It was observed that newly born neurons receive sequential innervation from structures important for memory function. Initially, septal-hippocampal cells provide input to new neurons, followed after about one month by perirhinal and lateral entorhinal cortex. These cortical areas are deemed relevant to encoding of novel environmental information and may enable pattern separation. Here, we review the developmental time-course and proposed functional relevance of new neurons, within the context of their unique neural circuitry.http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00015/fullDentate GyrusRabies virusRetrovirusPattern Separationlearning and memoryperirhinal cortex |
| spellingShingle | Carmen eVivar Henriette eVan Praag Functional circuits of new neurons in the dentate gyrus Frontiers in Neural Circuits Dentate Gyrus Rabies virus Retrovirus Pattern Separation learning and memory perirhinal cortex |
| title | Functional circuits of new neurons in the dentate gyrus |
| title_full | Functional circuits of new neurons in the dentate gyrus |
| title_fullStr | Functional circuits of new neurons in the dentate gyrus |
| title_full_unstemmed | Functional circuits of new neurons in the dentate gyrus |
| title_short | Functional circuits of new neurons in the dentate gyrus |
| title_sort | functional circuits of new neurons in the dentate gyrus |
| topic | Dentate Gyrus Rabies virus Retrovirus Pattern Separation learning and memory perirhinal cortex |
| url | http://journal.frontiersin.org/Journal/10.3389/fncir.2013.00015/full |
| work_keys_str_mv | AT carmenevivar functionalcircuitsofnewneuronsinthedentategyrus AT henrietteevanpraag functionalcircuitsofnewneuronsinthedentategyrus |