In Silico Analyses of a Promising Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis Targeting Superoxide Dismutase I Protein

In Silico Analyses of a Promising Drug Candidate for the Treatment of Amyotrophic Lateral Sclerosis Targeting Superoxide Dismutase I Protein

Amyotrophic lateral sclerosis (ALS) is the most prevalent motor neuron disorder in adults, which is associated with a highly disabling condition. To date, ALS remains incurable, and the only drugs approved by the FDA for its treatment confer a limited survival benefit. Recently, SOD1 binding ligand...

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Bibliographic Details
Main Authors: Gabriel Rodrigues Coutinho Pereira, Bárbara de Azevedo Abrahim-Vieira, Joelma Freire de Mesquita
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Pharmaceutics
Subjects:
amyotrophic lateral sclerosis
in silico
molecular dynamics
ADMET prediction
Online Access:https://www.mdpi.com/1999-4923/15/4/1095

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