Clinical Presentation and Severity of SARS-CoV-2 Infection Compared to Respiratory Syncytial Virus and Other Viral Respiratory Infections in Children Less than Two Years of Age
The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the implementation of restrictive measures led to a dramatic reduction in respiratory syncytial virus (RSV) occurrence together with rare and mild bronchiolitis induced by SARS-CoV-2. We described the respiratory picture...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-03-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/15/3/717 |
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| author | Francesco Nunziata Simona Salomone Andrea Catzola Marco Poeta Federica Pagano Liana Punzi Andrea Lo Vecchio Alfredo Guarino Eugenia Bruzzese |
| author_facet | Francesco Nunziata Simona Salomone Andrea Catzola Marco Poeta Federica Pagano Liana Punzi Andrea Lo Vecchio Alfredo Guarino Eugenia Bruzzese |
| author_sort | Francesco Nunziata |
| collection | DOAJ |
| description | The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the implementation of restrictive measures led to a dramatic reduction in respiratory syncytial virus (RSV) occurrence together with rare and mild bronchiolitis induced by SARS-CoV-2. We described the respiratory picture of SARS-CoV-2 infection and evaluated the frequency and the severity of SARS-CoV-2 bronchiolitis comparing it with other respiratory viral infections in children less than two years of age. The severity of respiratory involvement was evaluated based on the need for oxygen therapy, intravenous hydration, and the length of hospital stay. A total of 138 children hospitalized for respiratory symptoms were enrolled: 60 with SARS-CoV-2 and 78 with RSV. In the group of SARS-CoV-2-infected children, 13/60 (21%) received a diagnosis of co-infection. Among the enrolled children, 87/138 (63%) received a diagnosis of bronchiolitis. The comparative evaluation showed a higher risk of the need for oxygen therapy and intravenous hydration in children with RSV infection and co-infection compared to children with SARS-CoV-2 infection. In the children with a diagnosis of bronchiolitis, no differences in the main outcomes among the groups were observed. Although children with SARS-CoV-2 infection have less severe respiratory effects than adults, the pediatrician should pay attention to bronchiolitis due to SARS-CoV-2, which could have a severe clinical course in younger children. |
| first_indexed | 2024-03-11T05:45:39Z |
| format | Article |
| id | doaj.art-4668cef903c646498d7ac33ff8da47bf |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-11T05:45:39Z |
| publishDate | 2023-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-4668cef903c646498d7ac33ff8da47bf2023-11-17T14:23:21ZengMDPI AGViruses1999-49152023-03-0115371710.3390/v15030717Clinical Presentation and Severity of SARS-CoV-2 Infection Compared to Respiratory Syncytial Virus and Other Viral Respiratory Infections in Children Less than Two Years of AgeFrancesco Nunziata0Simona Salomone1Andrea Catzola2Marco Poeta3Federica Pagano4Liana Punzi5Andrea Lo Vecchio6Alfredo Guarino7Eugenia Bruzzese8Department of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, ItalyDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, ItalyPediatric Unit, OORR Area Stabiese, Castellammare di Stabia, 80053 Naples, ItalyDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, ItalyDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, ItalyDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, ItalyDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, ItalyDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, ItalyDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, 80131 Naples, ItalyThe spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the implementation of restrictive measures led to a dramatic reduction in respiratory syncytial virus (RSV) occurrence together with rare and mild bronchiolitis induced by SARS-CoV-2. We described the respiratory picture of SARS-CoV-2 infection and evaluated the frequency and the severity of SARS-CoV-2 bronchiolitis comparing it with other respiratory viral infections in children less than two years of age. The severity of respiratory involvement was evaluated based on the need for oxygen therapy, intravenous hydration, and the length of hospital stay. A total of 138 children hospitalized for respiratory symptoms were enrolled: 60 with SARS-CoV-2 and 78 with RSV. In the group of SARS-CoV-2-infected children, 13/60 (21%) received a diagnosis of co-infection. Among the enrolled children, 87/138 (63%) received a diagnosis of bronchiolitis. The comparative evaluation showed a higher risk of the need for oxygen therapy and intravenous hydration in children with RSV infection and co-infection compared to children with SARS-CoV-2 infection. In the children with a diagnosis of bronchiolitis, no differences in the main outcomes among the groups were observed. Although children with SARS-CoV-2 infection have less severe respiratory effects than adults, the pediatrician should pay attention to bronchiolitis due to SARS-CoV-2, which could have a severe clinical course in younger children.https://www.mdpi.com/1999-4915/15/3/717COVID-19bronchiolitischildrenSARS-CoV-2respiratory syncytial virus |
| spellingShingle | Francesco Nunziata Simona Salomone Andrea Catzola Marco Poeta Federica Pagano Liana Punzi Andrea Lo Vecchio Alfredo Guarino Eugenia Bruzzese Clinical Presentation and Severity of SARS-CoV-2 Infection Compared to Respiratory Syncytial Virus and Other Viral Respiratory Infections in Children Less than Two Years of Age Viruses COVID-19 bronchiolitis children SARS-CoV-2 respiratory syncytial virus |
| title | Clinical Presentation and Severity of SARS-CoV-2 Infection Compared to Respiratory Syncytial Virus and Other Viral Respiratory Infections in Children Less than Two Years of Age |
| title_full | Clinical Presentation and Severity of SARS-CoV-2 Infection Compared to Respiratory Syncytial Virus and Other Viral Respiratory Infections in Children Less than Two Years of Age |
| title_fullStr | Clinical Presentation and Severity of SARS-CoV-2 Infection Compared to Respiratory Syncytial Virus and Other Viral Respiratory Infections in Children Less than Two Years of Age |
| title_full_unstemmed | Clinical Presentation and Severity of SARS-CoV-2 Infection Compared to Respiratory Syncytial Virus and Other Viral Respiratory Infections in Children Less than Two Years of Age |
| title_short | Clinical Presentation and Severity of SARS-CoV-2 Infection Compared to Respiratory Syncytial Virus and Other Viral Respiratory Infections in Children Less than Two Years of Age |
| title_sort | clinical presentation and severity of sars cov 2 infection compared to respiratory syncytial virus and other viral respiratory infections in children less than two years of age |
| topic | COVID-19 bronchiolitis children SARS-CoV-2 respiratory syncytial virus |
| url | https://www.mdpi.com/1999-4915/15/3/717 |
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