The Role of Autophagy in Eye Diseases
Autophagy is a catabolic process that ensures homeostasis in the cells of our organism. It plays a crucial role in protecting eye cells against oxidative damage and external stress factors. Ocular pathologies of high incidence, such as age-related macular degeneration, cataracts, glaucoma, and diabe...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-02-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/11/3/189 |
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| author | José A. Fernández-Albarral Esther de Julián-López Carmen Soler-Domínguez Rosa de Hoz Inés López-Cuenca Elena Salobrar-García José M. Ramírez María D. Pinazo-Durán Juan J. Salazar Ana I. Ramírez |
| author_facet | José A. Fernández-Albarral Esther de Julián-López Carmen Soler-Domínguez Rosa de Hoz Inés López-Cuenca Elena Salobrar-García José M. Ramírez María D. Pinazo-Durán Juan J. Salazar Ana I. Ramírez |
| author_sort | José A. Fernández-Albarral |
| collection | DOAJ |
| description | Autophagy is a catabolic process that ensures homeostasis in the cells of our organism. It plays a crucial role in protecting eye cells against oxidative damage and external stress factors. Ocular pathologies of high incidence, such as age-related macular degeneration, cataracts, glaucoma, and diabetic retinopathy are of multifactorial origin and are associated with genetic, environmental factors, age, and oxidative stress, among others; the latter factor is one of the most influential in ocular diseases, directly affecting the processes of autophagy activity. Alteration of the normal functioning of autophagy processes can interrupt organelle turnover, leading to the accumulation of cellular debris and causing physiological dysfunction of the eye. The aim of this study is to review research on the role of autophagy processes in the main ocular pathologies, which have a high incidence and result in high costs for the health system. Considering the role of autophagy processes in cell homeostasis and cell viability, the control and modulation of autophagy processes in ocular pathologies could constitute a new therapeutic approach. |
| first_indexed | 2024-03-09T06:16:29Z |
| format | Article |
| id | doaj.art-466ce9f66f894a659ec99b5bcb4e432a |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T06:16:29Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-466ce9f66f894a659ec99b5bcb4e432a2023-12-03T11:52:42ZengMDPI AGLife2075-17292021-02-0111318910.3390/life11030189The Role of Autophagy in Eye DiseasesJosé A. Fernández-Albarral0Esther de Julián-López1Carmen Soler-Domínguez2Rosa de Hoz3Inés López-Cuenca4Elena Salobrar-García5José M. Ramírez6María D. Pinazo-Durán7Juan J. Salazar8Ana I. Ramírez9Instituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, SpainInstituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, SpainInstituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, SpainInstituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, SpainInstituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, SpainInstituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, SpainInstituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, SpainOFTARED: Spanish net of Ophthalmic Pathology, Institute of Health Carlos III, 28029 Madrid, SpainInstituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, SpainInstituto de Investigaciones Oftalmológicas Ramón Castroviejo, Universidad Complutense de Madrid (UCM), 28040 Madrid, SpainAutophagy is a catabolic process that ensures homeostasis in the cells of our organism. It plays a crucial role in protecting eye cells against oxidative damage and external stress factors. Ocular pathologies of high incidence, such as age-related macular degeneration, cataracts, glaucoma, and diabetic retinopathy are of multifactorial origin and are associated with genetic, environmental factors, age, and oxidative stress, among others; the latter factor is one of the most influential in ocular diseases, directly affecting the processes of autophagy activity. Alteration of the normal functioning of autophagy processes can interrupt organelle turnover, leading to the accumulation of cellular debris and causing physiological dysfunction of the eye. The aim of this study is to review research on the role of autophagy processes in the main ocular pathologies, which have a high incidence and result in high costs for the health system. Considering the role of autophagy processes in cell homeostasis and cell viability, the control and modulation of autophagy processes in ocular pathologies could constitute a new therapeutic approach.https://www.mdpi.com/2075-1729/11/3/189autophagyocular pathologyglaucomacataractdiabetic retinopathyAMD |
| spellingShingle | José A. Fernández-Albarral Esther de Julián-López Carmen Soler-Domínguez Rosa de Hoz Inés López-Cuenca Elena Salobrar-García José M. Ramírez María D. Pinazo-Durán Juan J. Salazar Ana I. Ramírez The Role of Autophagy in Eye Diseases Life autophagy ocular pathology glaucoma cataract diabetic retinopathy AMD |
| title | The Role of Autophagy in Eye Diseases |
| title_full | The Role of Autophagy in Eye Diseases |
| title_fullStr | The Role of Autophagy in Eye Diseases |
| title_full_unstemmed | The Role of Autophagy in Eye Diseases |
| title_short | The Role of Autophagy in Eye Diseases |
| title_sort | role of autophagy in eye diseases |
| topic | autophagy ocular pathology glaucoma cataract diabetic retinopathy AMD |
| url | https://www.mdpi.com/2075-1729/11/3/189 |
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