Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery
Solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsion (NE) of lornoxicam (LRX) were prepared for the treatment of painful and inflammatory conditions of the skin. Compritol® 888 ATO, Lanette® O and oleic acid were used as solid and liquid lipids. SLN, NLC and NE were...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2015-03-01
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| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/acph-2015-0009 |
| _version_ | 1818720572359573504 |
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| author | Gönüllü Ümit Üner Melike Yener Gülgün Karaman Ecem Fatma Aydoğmuş Zeynep |
| author_facet | Gönüllü Ümit Üner Melike Yener Gülgün Karaman Ecem Fatma Aydoğmuş Zeynep |
| author_sort | Gönüllü Ümit |
| collection | DOAJ |
| description | Solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsion (NE) of lornoxicam (LRX) were prepared for the treatment of painful and inflammatory conditions of the skin. Compritol® 888 ATO, Lanette® O and oleic acid were used as solid and liquid lipids. SLN, NLC and NE were found physically stable at various temperatures for 6 months. Case I diffusional drug release was detected as the dominant mechanism indicating Fickian drug diffusion from nanoparticles and nanoemulsion. The highest rate of drug penetration through rat skin was obtained with NE followed by NLC, SLN and a gel formulation. Nanoformulations significantly increased drug penetration through rat skin compared to the gel (p < 0.05). Thus, SLN, NLC and NE of LRX can be suggested for relieving painful and inflammatory conditions of the skin |
| first_indexed | 2024-12-17T20:24:58Z |
| format | Article |
| id | doaj.art-466d987a499446c6bc3fe6d7d54535e6 |
| institution | Directory Open Access Journal |
| issn | 1846-9558 |
| language | English |
| last_indexed | 2024-12-17T20:24:58Z |
| publishDate | 2015-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj.art-466d987a499446c6bc3fe6d7d54535e62022-12-21T21:33:50ZengSciendoActa Pharmaceutica1846-95582015-03-0165111310.1515/acph-2015-0009acph-2015-0009Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal deliveryGönüllü Ümit0Üner Melike1Yener Gülgün2Karaman Ecem Fatma3Aydoğmuş Zeynep4Istanbul University Faculty of Pharmacy Department of Pharmaceutical Technology, Istanbul, TurkeyIstanbul University Faculty of Pharmacy Department of Pharmaceutical Technology, Istanbul, TurkeyIstanbul University Faculty of Pharmacy Department of Pharmaceutical Technology, Istanbul, TurkeyIstanbul University Faculty of Pharmacy Department of Pharmaceutical Technology, Istanbul, TurkeyIstanbul University Faculty of Pharmacy Department of Analytical Chemistry Istanbul, TurkeySolid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsion (NE) of lornoxicam (LRX) were prepared for the treatment of painful and inflammatory conditions of the skin. Compritol® 888 ATO, Lanette® O and oleic acid were used as solid and liquid lipids. SLN, NLC and NE were found physically stable at various temperatures for 6 months. Case I diffusional drug release was detected as the dominant mechanism indicating Fickian drug diffusion from nanoparticles and nanoemulsion. The highest rate of drug penetration through rat skin was obtained with NE followed by NLC, SLN and a gel formulation. Nanoformulations significantly increased drug penetration through rat skin compared to the gel (p < 0.05). Thus, SLN, NLC and NE of LRX can be suggested for relieving painful and inflammatory conditions of the skinhttps://doi.org/10.1515/acph-2015-0009lornoxicamsolid lipid nanoparticlesnanostructured lipid carriersnanoemulsiontransdermal deliveryinflammation |
| spellingShingle | Gönüllü Ümit Üner Melike Yener Gülgün Karaman Ecem Fatma Aydoğmuş Zeynep Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery Acta Pharmaceutica lornoxicam solid lipid nanoparticles nanostructured lipid carriers nanoemulsion transdermal delivery inflammation |
| title | Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery |
| title_full | Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery |
| title_fullStr | Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery |
| title_full_unstemmed | Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery |
| title_short | Formulation and characterization of solid lipid nanoparticles, nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery |
| title_sort | formulation and characterization of solid lipid nanoparticles nanostructured lipid carriers and nanoemulsion of lornoxicam for transdermal delivery |
| topic | lornoxicam solid lipid nanoparticles nanostructured lipid carriers nanoemulsion transdermal delivery inflammation |
| url | https://doi.org/10.1515/acph-2015-0009 |
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