Serum Soluble Adhesion Molecules (sICAM-1, sVCAM-1, sE-selectin) and Neopterin in Patients with Sjögren's Syndrome
Sjögren's syndrome is a systemic autoimmune disease characterized by focal lymphocytic infiltration of the salivary and lacrimal glands. Expression and up-regulation of adhesion molecules and activation of cellular immune system is essential for the migration of inflammatory cells into tissues....
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Karolinum Press
1999-01-01
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| Series: | Acta Medica |
| Subjects: | |
| Online Access: | https://actamedica.lfhk.cuni.cz/42/3/0097/ |
| _version_ | 1811293758598152192 |
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| author | Ctirad Andrýs Jan Krejsek Radovan Slezák Marcela Drahošová Otakar Kopecký |
| author_facet | Ctirad Andrýs Jan Krejsek Radovan Slezák Marcela Drahošová Otakar Kopecký |
| author_sort | Ctirad Andrýs |
| collection | DOAJ |
| description | Sjögren's syndrome is a systemic autoimmune disease characterized by focal lymphocytic infiltration of the salivary and lacrimal glands. Expression and up-regulation of adhesion molecules and activation of cellular immune system is essential for the migration of inflammatory cells into tissues. Soluble forms of adhesion molecules sICAM-1, sVCAM-1, sE-selectin and neopterin were analyzed in serum of 17 patients with primary Sjögren's syndrome and 11 patients with secondary Sjögren's syndrome together with 26 age-matched healthy blood donors. There were significantly higher serum concentrations (mean ± 1SD) of sICAM-1 (362.0 ± 67.9 ng/ml, p<0.001), sE-selectin (78.7 ± 28.1 ng/ml, p<0.001) and neopterin (17.9 ± 6.4 nmol/l, p<0.001) in primary Sjögren's syndrome patients in comparison to control group (sICAM-1: 128.3 ± 46.9 ng/ml, sE-selectin: 46.3 ± 39.5 ng/ml, and neopterin: 7.6 ± 2.3 nmol/l). Sera from patients with secondary Sjögren's disease contained significantly higher levels of sICAM-1 (356.0 ± 62.4 ng/ml, p<0.001), sE-selectin (65.5 ± 27.0 ng/ml, p<0.05), and neopterin (18.8 ± 9.8 nmol/l, p<0.001) in comparison with control group. There were no significant differences between patients with primary and secondary Sjögren's syndrome in any parameters tested. No statistically significant differences in serum levels of sVCAM-1 were found either in patients with primary or secondary SS compared to control group. |
| first_indexed | 2024-04-13T05:06:10Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1211-4286 1805-9694 |
| language | English |
| last_indexed | 2024-04-13T05:06:10Z |
| publishDate | 1999-01-01 |
| publisher | Karolinum Press |
| record_format | Article |
| series | Acta Medica |
| spelling | doaj.art-466ebf38b1f3433f8395f84023f6280d2022-12-22T03:01:10ZengKarolinum PressActa Medica1211-42861805-96941999-01-014239710110.14712/18059694.2019.151Serum Soluble Adhesion Molecules (sICAM-1, sVCAM-1, sE-selectin) and Neopterin in Patients with Sjögren's SyndromeCtirad Andrýs0Jan Krejsek1Radovan Slezák2Marcela Drahošová3Otakar Kopecký4University Teaching Hospital in Hradec Králové, Department of Clinical Immunology and Allergology, Hradec Králové, Czech RepublicCharles University in Prague, Faculty of Medicine in Hradec Králové, Department of Clinical Immunology and Allergology, Hradec Králové, Czech RepublicCharles University in Prague, Faculty of Medicine in Hradec Králové, Department of Dentistry, Hradec Králové, Czech RepublicUniversity Teaching Hospital in Hradec Králové, Department of Clinical Immunology and Allergology, Hradec Králové, Czech RepublicCharles University in Prague, Faculty of Medicine in Hradec Králové, Department of Clinical Immunology and Allergology, Hradec Králové, Czech RepublicSjögren's syndrome is a systemic autoimmune disease characterized by focal lymphocytic infiltration of the salivary and lacrimal glands. Expression and up-regulation of adhesion molecules and activation of cellular immune system is essential for the migration of inflammatory cells into tissues. Soluble forms of adhesion molecules sICAM-1, sVCAM-1, sE-selectin and neopterin were analyzed in serum of 17 patients with primary Sjögren's syndrome and 11 patients with secondary Sjögren's syndrome together with 26 age-matched healthy blood donors. There were significantly higher serum concentrations (mean ± 1SD) of sICAM-1 (362.0 ± 67.9 ng/ml, p<0.001), sE-selectin (78.7 ± 28.1 ng/ml, p<0.001) and neopterin (17.9 ± 6.4 nmol/l, p<0.001) in primary Sjögren's syndrome patients in comparison to control group (sICAM-1: 128.3 ± 46.9 ng/ml, sE-selectin: 46.3 ± 39.5 ng/ml, and neopterin: 7.6 ± 2.3 nmol/l). Sera from patients with secondary Sjögren's disease contained significantly higher levels of sICAM-1 (356.0 ± 62.4 ng/ml, p<0.001), sE-selectin (65.5 ± 27.0 ng/ml, p<0.05), and neopterin (18.8 ± 9.8 nmol/l, p<0.001) in comparison with control group. There were no significant differences between patients with primary and secondary Sjögren's syndrome in any parameters tested. No statistically significant differences in serum levels of sVCAM-1 were found either in patients with primary or secondary SS compared to control group.https://actamedica.lfhk.cuni.cz/42/3/0097/NeopterinsE-selectinsICAM-1Sjögren's syndromesVCAM-1 |
| spellingShingle | Ctirad Andrýs Jan Krejsek Radovan Slezák Marcela Drahošová Otakar Kopecký Serum Soluble Adhesion Molecules (sICAM-1, sVCAM-1, sE-selectin) and Neopterin in Patients with Sjögren's Syndrome Acta Medica Neopterin sE-selectin sICAM-1 Sjögren's syndrome sVCAM-1 |
| title | Serum Soluble Adhesion Molecules (sICAM-1, sVCAM-1, sE-selectin) and Neopterin in Patients with Sjögren's Syndrome |
| title_full | Serum Soluble Adhesion Molecules (sICAM-1, sVCAM-1, sE-selectin) and Neopterin in Patients with Sjögren's Syndrome |
| title_fullStr | Serum Soluble Adhesion Molecules (sICAM-1, sVCAM-1, sE-selectin) and Neopterin in Patients with Sjögren's Syndrome |
| title_full_unstemmed | Serum Soluble Adhesion Molecules (sICAM-1, sVCAM-1, sE-selectin) and Neopterin in Patients with Sjögren's Syndrome |
| title_short | Serum Soluble Adhesion Molecules (sICAM-1, sVCAM-1, sE-selectin) and Neopterin in Patients with Sjögren's Syndrome |
| title_sort | serum soluble adhesion molecules sicam 1 svcam 1 se selectin and neopterin in patients with sjogren s syndrome |
| topic | Neopterin sE-selectin sICAM-1 Sjögren's syndrome sVCAM-1 |
| url | https://actamedica.lfhk.cuni.cz/42/3/0097/ |
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