A novel Oprm1-Cre mouse maintains endogenous expression, function and enables detailed molecular characterization of μ-opioid receptor cells.

A novel Oprm1-Cre mouse maintains endogenous expression, function and enables detailed molecular characterization of μ-opioid receptor cells.

Key targets of both the therapeutic and abused properties of opioids are μ-opioid receptors (MORs). Despite years of research investigating the biochemistry and signal transduction pathways associated with MOR activation, we do not fully understand the cellular mechanisms underlying opioid addiction...

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Bibliographic Details
Main Authors: Juliet Mengaziol, Amelia D Dunn, Gregory Salimando, Lisa Wooldridge, Jordi Crues-Muncunill, Darrell Eacret, Chongguang Chen, Kathryn Bland, Lee-Yuan Liu-Chen, Michelle E Ehrlich, Gregory Corder, Julie A Blendy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0270317

Internet

https://doi.org/10.1371/journal.pone.0270317

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