Characteristics and Prognosis of Triple-Negative Breast Cancer Patients: a Croatian Single Institution Retrospective Cohort Study
Triple-negative breast cancer (TNBC) occurs in around one-sixth of all breast cancer (BC) patients, with the most aggressive behavior and worst prognosis of all BC subtypes. It is a heterogeneous disease, with specific molecular characteristics and natural dynamics of early recurrence and fast progr...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Sestre Milosrdnice University hospital, Institute of Clinical Medical Research
2020-01-01
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| Series: | Acta Clinica Croatica |
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| Online Access: | https://hrcak.srce.hr/file/351936 |
| _version_ | 1797207202500444160 |
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| author | Ana Tečić Vuger Robert Šeparović Ljubica Vazdar Mirjana Pavlović Petra Lepetić Sanda Šitić Žarko Bajić Božena Šarčević Damir Vrbanec |
| author_facet | Ana Tečić Vuger Robert Šeparović Ljubica Vazdar Mirjana Pavlović Petra Lepetić Sanda Šitić Žarko Bajić Božena Šarčević Damir Vrbanec |
| author_sort | Ana Tečić Vuger |
| collection | DOAJ |
| description | Triple-negative breast cancer (TNBC) occurs in around one-sixth of all breast cancer (BC) patients, with the most aggressive behavior and worst prognosis of all BC subtypes. It is a heterogeneous disease, with specific molecular characteristics and natural dynamics of early recurrence and fast progression. Due to the lack of biomarkers or any valid treatment targets, it can only be treated with classic cytotoxic chemotherapy. We analyzed a cohort of 152 patients, median age 58
years, diagnosed with and treated for early stage TNBC at the University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia, during the 2009-2012 period. Patients were
treated with primary surgical approach, adjuvant chemotherapy and adjuvant irradiation. We observed a relatively large proportion of locally advanced TNBC at diagnosis, with large tumor size and nodal involvement, with high grade and high proliferation index Ki67. Patient age, tumor size and lymph node involvement, as expected, were significant and clinically most important prognostic factors for 5-year disease-free survival (67%; 95% CI 60%-75%) and overall absolute survival rate (74%; 95% CI 66%-81%). |
| first_indexed | 2024-04-24T09:19:10Z |
| format | Article |
| id | doaj.art-46703ac2ee474f09acb499d757115aa0 |
| institution | Directory Open Access Journal |
| issn | 0353-9466 1333-9451 |
| language | English |
| last_indexed | 2024-04-24T09:19:10Z |
| publishDate | 2020-01-01 |
| publisher | Sestre Milosrdnice University hospital, Institute of Clinical Medical Research |
| record_format | Article |
| series | Acta Clinica Croatica |
| spelling | doaj.art-46703ac2ee474f09acb499d757115aa02024-04-15T16:21:50ZengSestre Milosrdnice University hospital, Institute of Clinical Medical ResearchActa Clinica Croatica0353-94661333-94512020-01-0159.1.9710710.20471/acc.2020.59.01.12Characteristics and Prognosis of Triple-Negative Breast Cancer Patients: a Croatian Single Institution Retrospective Cohort StudyAna Tečić Vuger0Robert Šeparović1Ljubica Vazdar2Mirjana Pavlović3Petra Lepetić4Sanda Šitić5Žarko Bajić6Božena Šarčević7Damir Vrbanec8Department of Medical Oncology, Division of Radiotherapy and Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, CroatiaDepartment of Medical Oncology, Division of Radiotherapy and Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia; School of Medicine, Juraj Dobrila University, Pula, CroatiaDepartment of Medical Oncology, Division of Radiotherapy and Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, CroatiaDepartment of Medical Oncology, Division of Radiotherapy and Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, CroatiaDepartment of Medical Oncology, Division of Radiotherapy and Medical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, CroatiaDepartment of Oncologic Cytology and Pathology, University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, CroatiaDr. Mirko Grmek Scientific Unit, Sveti Ivan Psychiatric Hospital, Zagreb, CroatiaSchool of Medicine, University of Zagreb, Zagreb, CroatiaSchool of Medicine, Juraj Dobrila University, Pula, CroatiaTriple-negative breast cancer (TNBC) occurs in around one-sixth of all breast cancer (BC) patients, with the most aggressive behavior and worst prognosis of all BC subtypes. It is a heterogeneous disease, with specific molecular characteristics and natural dynamics of early recurrence and fast progression. Due to the lack of biomarkers or any valid treatment targets, it can only be treated with classic cytotoxic chemotherapy. We analyzed a cohort of 152 patients, median age 58 years, diagnosed with and treated for early stage TNBC at the University Hospital for Tumors, Sestre milosrdnice University Hospital Centre, Zagreb, Croatia, during the 2009-2012 period. Patients were treated with primary surgical approach, adjuvant chemotherapy and adjuvant irradiation. We observed a relatively large proportion of locally advanced TNBC at diagnosis, with large tumor size and nodal involvement, with high grade and high proliferation index Ki67. Patient age, tumor size and lymph node involvement, as expected, were significant and clinically most important prognostic factors for 5-year disease-free survival (67%; 95% CI 60%-75%) and overall absolute survival rate (74%; 95% CI 66%-81%).https://hrcak.srce.hr/file/351936Triple negative breast cancerEarly diseaseAdjuvant treatmentLymph nodeDisease free survivalOverall survival |
| spellingShingle | Ana Tečić Vuger Robert Šeparović Ljubica Vazdar Mirjana Pavlović Petra Lepetić Sanda Šitić Žarko Bajić Božena Šarčević Damir Vrbanec Characteristics and Prognosis of Triple-Negative Breast Cancer Patients: a Croatian Single Institution Retrospective Cohort Study Acta Clinica Croatica Triple negative breast cancer Early disease Adjuvant treatment Lymph node Disease free survival Overall survival |
| title | Characteristics and Prognosis of Triple-Negative Breast Cancer Patients: a Croatian Single Institution Retrospective Cohort Study |
| title_full | Characteristics and Prognosis of Triple-Negative Breast Cancer Patients: a Croatian Single Institution Retrospective Cohort Study |
| title_fullStr | Characteristics and Prognosis of Triple-Negative Breast Cancer Patients: a Croatian Single Institution Retrospective Cohort Study |
| title_full_unstemmed | Characteristics and Prognosis of Triple-Negative Breast Cancer Patients: a Croatian Single Institution Retrospective Cohort Study |
| title_short | Characteristics and Prognosis of Triple-Negative Breast Cancer Patients: a Croatian Single Institution Retrospective Cohort Study |
| title_sort | characteristics and prognosis of triple negative breast cancer patients a croatian single institution retrospective cohort study |
| topic | Triple negative breast cancer Early disease Adjuvant treatment Lymph node Disease free survival Overall survival |
| url | https://hrcak.srce.hr/file/351936 |
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