Synthesis and Structure–Activity Relationship of Salvinal Derivatives as Potent Microtubule Inhibitors

Synthesis and Structure–Activity Relationship of Salvinal Derivatives as Potent Microtubule Inhibitors

Salvinal is a natural lignan isolated from the roots of <i>Salvia mitorrhiza</i> Bunge (Danshen). Previous studies have demonstrated its anti-proliferative activity in both drug-sensitive and -resistant cancer cell lines, with IC<sub>50</sub> values ranging from 4–17 µM. In t...

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Main Authors: Chi-I Chang, Cheng-Chih Hsieh, Yung-Shung Wein, Ching-Chuan Kuo, Chi-Yen Chang, Jrhau Lung, Jong-Yuh Cherng, Po-Chen Chu, Jang-Yang Chang, Yueh-Hsiung Kuo
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
salvinal
lignan
<i>Salvia mitorrhiza</i>
anticancer
microtubule depolymerization
Online Access:https://www.mdpi.com/1422-0067/24/7/6386

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