Is There Really a Difference in Outcomes between Men and Women with Hepatocellular Cancer?
Hepatocellular carcinoma (HCC) is a male-dominated disease. Currently, gender differences remain incompletely defined. Data from the state tumor registry were used to investigate differences in demographics, comorbidities, treatment patterns, and cancer-specific survival (HSS) among HCC patients acc...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/11/2892 |
| _version_ | 1797597790479581184 |
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| author | Andrea Fa Denise M. Danos Lauren Maniscalco Yong Yi Xiao-Cheng Wu Mary A. Maluccio Quyen D. Chu John M. Lyons |
| author_facet | Andrea Fa Denise M. Danos Lauren Maniscalco Yong Yi Xiao-Cheng Wu Mary A. Maluccio Quyen D. Chu John M. Lyons |
| author_sort | Andrea Fa |
| collection | DOAJ |
| description | Hepatocellular carcinoma (HCC) is a male-dominated disease. Currently, gender differences remain incompletely defined. Data from the state tumor registry were used to investigate differences in demographics, comorbidities, treatment patterns, and cancer-specific survival (HSS) among HCC patients according to gender. Additional analyses were performed to evaluate racial differences among women with HCC. 2627 patients with HCC were included; 498 (19%) were women. Women were mostly white (58%) or African American (39%)—only 3.8% were of another or unknown race. Women were older (65.1 vs. 61.3 years), more obese (33.7% vs. 24.2%), and diagnosed at an earlier stage (31.7% vs. 28.4%) than men. Women had a lower incidence of liver associated comorbidities (36.1% vs. 43%), and more often underwent liver-directed surgery (LDS; 27.5% vs. 22%). When controlling for LDS, no survival differences were observed between genders. African American women had similar HSS rates compared to white women (HR 1.14 (0.91,1.41), <i>p</i> = 0.239) despite having different residential and treatment geographical distributions. African American race and age >65 were predictive for worse HSS in men, but not in women. Overall, women with HCC undergo more treatment options—likely because of the earlier stage of the cancer and/or less severe underlying liver disease. However, when controlling for similar stages and treatments, HCC treatment outcomes were similar between men and women. African American race did not appear to influence outcomes among women with HCC as it did in men. |
| first_indexed | 2024-03-11T03:10:26Z |
| format | Article |
| id | doaj.art-46728b03d2a445ceb3ce873917e0d3bb |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T03:10:26Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-46728b03d2a445ceb3ce873917e0d3bb2023-11-18T07:37:58ZengMDPI AGCancers2072-66942023-05-011511289210.3390/cancers15112892Is There Really a Difference in Outcomes between Men and Women with Hepatocellular Cancer?Andrea Fa0Denise M. Danos1Lauren Maniscalco2Yong Yi3Xiao-Cheng Wu4Mary A. Maluccio5Quyen D. Chu6John M. Lyons7School of Medicine, LSU Health Sciences Center-New Orleans, New Orleans, LA 70112, USASchool of Public Health, LSU Health Science Center-New Orleans, New Orleans, LA 70112, USALouisiana Tumor Registry, School of Public Health, LSU Health Science Center-New Orleans, New Orleans, LA 70112, USALouisiana Tumor Registry, School of Public Health, LSU Health Science Center-New Orleans, New Orleans, LA 70112, USALouisiana Tumor Registry, School of Public Health, LSU Health Science Center-New Orleans, New Orleans, LA 70112, USASchool of Medicine, LSU Health Sciences Center-New Orleans, New Orleans, LA 70112, USAOrlando Health Cancer Institute, Orlando, FL 32806, USASchool of Medicine, LSU Health Sciences Center-New Orleans, New Orleans, LA 70112, USAHepatocellular carcinoma (HCC) is a male-dominated disease. Currently, gender differences remain incompletely defined. Data from the state tumor registry were used to investigate differences in demographics, comorbidities, treatment patterns, and cancer-specific survival (HSS) among HCC patients according to gender. Additional analyses were performed to evaluate racial differences among women with HCC. 2627 patients with HCC were included; 498 (19%) were women. Women were mostly white (58%) or African American (39%)—only 3.8% were of another or unknown race. Women were older (65.1 vs. 61.3 years), more obese (33.7% vs. 24.2%), and diagnosed at an earlier stage (31.7% vs. 28.4%) than men. Women had a lower incidence of liver associated comorbidities (36.1% vs. 43%), and more often underwent liver-directed surgery (LDS; 27.5% vs. 22%). When controlling for LDS, no survival differences were observed between genders. African American women had similar HSS rates compared to white women (HR 1.14 (0.91,1.41), <i>p</i> = 0.239) despite having different residential and treatment geographical distributions. African American race and age >65 were predictive for worse HSS in men, but not in women. Overall, women with HCC undergo more treatment options—likely because of the earlier stage of the cancer and/or less severe underlying liver disease. However, when controlling for similar stages and treatments, HCC treatment outcomes were similar between men and women. African American race did not appear to influence outcomes among women with HCC as it did in men.https://www.mdpi.com/2072-6694/15/11/2892hepatocellular cancerLouisianaincidencewomendisparities |
| spellingShingle | Andrea Fa Denise M. Danos Lauren Maniscalco Yong Yi Xiao-Cheng Wu Mary A. Maluccio Quyen D. Chu John M. Lyons Is There Really a Difference in Outcomes between Men and Women with Hepatocellular Cancer? Cancers hepatocellular cancer Louisiana incidence women disparities |
| title | Is There Really a Difference in Outcomes between Men and Women with Hepatocellular Cancer? |
| title_full | Is There Really a Difference in Outcomes between Men and Women with Hepatocellular Cancer? |
| title_fullStr | Is There Really a Difference in Outcomes between Men and Women with Hepatocellular Cancer? |
| title_full_unstemmed | Is There Really a Difference in Outcomes between Men and Women with Hepatocellular Cancer? |
| title_short | Is There Really a Difference in Outcomes between Men and Women with Hepatocellular Cancer? |
| title_sort | is there really a difference in outcomes between men and women with hepatocellular cancer |
| topic | hepatocellular cancer Louisiana incidence women disparities |
| url | https://www.mdpi.com/2072-6694/15/11/2892 |
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