Microbiome recovery in adult females with uncomplicated urinary tract infections in a randomised phase 2A trial of the novel antibiotic gepotidacin (GSK140944)

Microbiome recovery in adult females with uncomplicated urinary tract infections in a randomised phase 2A trial of the novel antibiotic gepotidacin (GSK140944)

Abstract Background With increasing concerns about the impact of frequent antibiotic usage on the human microbiome, it is important to characterize the potential for such effects in early antibiotic drug development clinical trials. In a randomised Phase 2a clinical trial study that evaluated the ph...

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Bibliographic Details
Main Authors: Andrea Nuzzo, Stephanie Van Horn, Christopher Traini, Caroline R. Perry, Etienne F. Dumont, Nicole E. Scangarella-Oman, David F. Gardiner, James R. Brown
Format: Article
Language:English
Published: BMC 2021-06-01
Series:BMC Microbiology
Subjects:
Gepotidacin
Microbiome
Antibiotic
Clinical trial
Urinary tract infection
Online Access:https://doi.org/10.1186/s12866-021-02245-8

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