Evaluation of dynamic serum thiol/disulfide homeostasis in locally advanced and metastatic gastric cancer
Background: Gastric cancer is one the most diagnosed cancer and the third leading cause of death from cancer worldwide. As an indicator of antioxidant capacity thiol/disulfide homeostasis regulates detoxification, cell signal mechanisms, apoptosis, transcription and antioxidant defense mechanisms. D...
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| Format: | Article |
| Language: | English |
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Turkiye Klinikleri
2018-04-01
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| Series: | Journal of Oncological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452336417301334 |
| _version_ | 1828019429869355008 |
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| author | Mutlu Hizal Mehmet A.N. Sendur Burak Bilgin Muhammed Bulent Akinci Didem Sener Dede Salim Neselioglu Ozcan Erel Bulent Yalcin |
| author_facet | Mutlu Hizal Mehmet A.N. Sendur Burak Bilgin Muhammed Bulent Akinci Didem Sener Dede Salim Neselioglu Ozcan Erel Bulent Yalcin |
| author_sort | Mutlu Hizal |
| collection | DOAJ |
| description | Background: Gastric cancer is one the most diagnosed cancer and the third leading cause of death from cancer worldwide. As an indicator of antioxidant capacity thiol/disulfide homeostasis regulates detoxification, cell signal mechanisms, apoptosis, transcription and antioxidant defense mechanisms. Disregulation of thiol/disulfide homeostasis identified in other cancer types by recent data. In this study, we aimed to evaluate the thiol/disulfide homeostasis in advanced gastric cancer patients. Methods: The patients who diagnosed with gastric cancer and healthy control subjects were included to study. Serum samples for the thiol-disulphide test were obtained at the time of diagnosis. Thiol-disulphide homeostasis tests were measured by the automated spectrophotometric method. Thiol-disulphide homeostasis was also measured according to clinical and laboratory features. Results: Thirty newly diagnosed advanced gastric adenocarcinoma patients and 28 healthy controls were enrolled in the study. The native thiol (NT) and total thiol (TT) levels of patients' group were significantly lower compared with controls (p = 0.001 and p < 0.001). In the CEA high (≥5.4 ng/ml) group, DS/NT ratio were higher compared with CEA low (<5.4 ng/ml) group (p = 0.024). In CA.19-9 high (≥28.3 kU/L) group, both DS and DS/NT ratio were significantly higher compared with a CA19-9 low(<28.3 kU/L) group (p < 0.05 both). The correlation between CEA and DS levels was also significant (p = 0.02). There was also a positive correlation between CEA levels and DS/NT ratio (p = 0.01). Conclusion: Derangements of thiol/disulfide homeostasis may have a role in gastric cancer pathogenesis and the higher level of oxidative stress may relate to extensive and aggressiveness of the advanced disease. The diagnostic and prognostic values of thiol/disulfide products need to identify with further studies. Keywords: Thiol, Disulfide, Oxidative stress, Gastric cancer, Metastatic |
| first_indexed | 2024-04-10T11:19:49Z |
| format | Article |
| id | doaj.art-467467e5c6164620af60b80ff161ba09 |
| institution | Directory Open Access Journal |
| issn | 2452-3364 |
| language | English |
| last_indexed | 2024-04-10T11:19:49Z |
| publishDate | 2018-04-01 |
| publisher | Turkiye Klinikleri |
| record_format | Article |
| series | Journal of Oncological Sciences |
| spelling | doaj.art-467467e5c6164620af60b80ff161ba092023-02-15T16:18:41ZengTurkiye KlinikleriJournal of Oncological Sciences2452-33642018-04-014114Evaluation of dynamic serum thiol/disulfide homeostasis in locally advanced and metastatic gastric cancerMutlu Hizal0Mehmet A.N. Sendur1Burak Bilgin2Muhammed Bulent Akinci3Didem Sener Dede4Salim Neselioglu5Ozcan Erel6Bulent Yalcin7Yildirim Beyazit University, Faculty of Medicine, Department of Medical Oncology, Ankara, Turkey; Corresponding author.Yildirim Beyazit University, Faculty of Medicine, Department of Medical Oncology, Ankara, TurkeyYildirim Beyazit University, Faculty of Medicine, Department of Medical Oncology, Ankara, TurkeyYildirim Beyazit University, Faculty of Medicine, Department of Medical Oncology, Ankara, TurkeyYildirim Beyazit University, Faculty of Medicine, Department of Medical Oncology, Ankara, TurkeyYildirim Beyazit University, Faculty of Medicine, Department of Biochemistry, Ankara, TurkeyYildirim Beyazit University, Faculty of Medicine, Department of Biochemistry, Ankara, TurkeyYildirim Beyazit University, Faculty of Medicine, Department of Medical Oncology, Ankara, TurkeyBackground: Gastric cancer is one the most diagnosed cancer and the third leading cause of death from cancer worldwide. As an indicator of antioxidant capacity thiol/disulfide homeostasis regulates detoxification, cell signal mechanisms, apoptosis, transcription and antioxidant defense mechanisms. Disregulation of thiol/disulfide homeostasis identified in other cancer types by recent data. In this study, we aimed to evaluate the thiol/disulfide homeostasis in advanced gastric cancer patients. Methods: The patients who diagnosed with gastric cancer and healthy control subjects were included to study. Serum samples for the thiol-disulphide test were obtained at the time of diagnosis. Thiol-disulphide homeostasis tests were measured by the automated spectrophotometric method. Thiol-disulphide homeostasis was also measured according to clinical and laboratory features. Results: Thirty newly diagnosed advanced gastric adenocarcinoma patients and 28 healthy controls were enrolled in the study. The native thiol (NT) and total thiol (TT) levels of patients' group were significantly lower compared with controls (p = 0.001 and p < 0.001). In the CEA high (≥5.4 ng/ml) group, DS/NT ratio were higher compared with CEA low (<5.4 ng/ml) group (p = 0.024). In CA.19-9 high (≥28.3 kU/L) group, both DS and DS/NT ratio were significantly higher compared with a CA19-9 low(<28.3 kU/L) group (p < 0.05 both). The correlation between CEA and DS levels was also significant (p = 0.02). There was also a positive correlation between CEA levels and DS/NT ratio (p = 0.01). Conclusion: Derangements of thiol/disulfide homeostasis may have a role in gastric cancer pathogenesis and the higher level of oxidative stress may relate to extensive and aggressiveness of the advanced disease. The diagnostic and prognostic values of thiol/disulfide products need to identify with further studies. Keywords: Thiol, Disulfide, Oxidative stress, Gastric cancer, Metastatichttp://www.sciencedirect.com/science/article/pii/S2452336417301334 |
| spellingShingle | Mutlu Hizal Mehmet A.N. Sendur Burak Bilgin Muhammed Bulent Akinci Didem Sener Dede Salim Neselioglu Ozcan Erel Bulent Yalcin Evaluation of dynamic serum thiol/disulfide homeostasis in locally advanced and metastatic gastric cancer Journal of Oncological Sciences |
| title | Evaluation of dynamic serum thiol/disulfide homeostasis in locally advanced and metastatic gastric cancer |
| title_full | Evaluation of dynamic serum thiol/disulfide homeostasis in locally advanced and metastatic gastric cancer |
| title_fullStr | Evaluation of dynamic serum thiol/disulfide homeostasis in locally advanced and metastatic gastric cancer |
| title_full_unstemmed | Evaluation of dynamic serum thiol/disulfide homeostasis in locally advanced and metastatic gastric cancer |
| title_short | Evaluation of dynamic serum thiol/disulfide homeostasis in locally advanced and metastatic gastric cancer |
| title_sort | evaluation of dynamic serum thiol disulfide homeostasis in locally advanced and metastatic gastric cancer |
| url | http://www.sciencedirect.com/science/article/pii/S2452336417301334 |
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