Seroma change during magnetic resonance imaging-guided partial breast irradiation and its clinical implications
Abstract Background To investigate the patterns of post-lumpectomy seroma volume (SV) change and related clinical factors to determine the benefits of adaptive planning in magnetic resonance imaging (MRI)-guided partial breast irradiation (PBI). Methods MRI data obtained from 37 women with early bre...
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| Format: | Article |
| Language: | English |
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BMC
2017-06-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13014-017-0843-7 |
| _version_ | 1811321468102901760 |
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| author | Seung Hyuck Jeon Kyung Hwan Shin So-Yeon Park Jung-in Kim Jong Min Park Jin Ho Kim Eui Kyu Chie Hong-Gyun Wu |
| author_facet | Seung Hyuck Jeon Kyung Hwan Shin So-Yeon Park Jung-in Kim Jong Min Park Jin Ho Kim Eui Kyu Chie Hong-Gyun Wu |
| author_sort | Seung Hyuck Jeon |
| collection | DOAJ |
| description | Abstract Background To investigate the patterns of post-lumpectomy seroma volume (SV) change and related clinical factors to determine the benefits of adaptive planning in magnetic resonance imaging (MRI)-guided partial breast irradiation (PBI). Methods MRI data obtained from 37 women with early breast cancer acquired at simulation and at the 1st, 6th, and 10th fractions were analyzed. The planning target volume (PTV) was defined as unequal margins of 10–15 mm added according to the directional surgical margin status of each seroma. Treatment was performed using a 0.35 T MRI-guided radiotherapy system. Univariate analysis was performed to assess the correlations between SV change rate and clinical factors. Seroma and PTV for adaptive planning were based on the images obtained at the 6th fraction. Results The average time intervals between surgery-simulation, simulation-1st, 1st-6th, and 6th-10th fractions were 23.1, 8.5, 7.2, and 5.9 days, respectively. Of the 37 patients, 33 exhibited decreased SV over the treatment period. The mean SV of these 33 patients decreased from 100% at simulation to 60, 48, and 40% at each MRI scan. In most cases (26/33), the logarithm of SV was inversely proportional to the elapsed time from surgery (R 2 > 0.90, Pearson’s correlation test). The volume of spared normal tissue from adaptive radiotherapy was proportional to the absolute change in SV (R 2 = 0.89, Pearson’s correlation test). Conclusion Seromas exhibit exponential shrinkage over the course of PBI. In patients receiving PBI, frequent monitoring of SV could be helpful in decision-making regarding adaptive planning, especially those with a large seroma. |
| first_indexed | 2024-04-13T13:18:18Z |
| format | Article |
| id | doaj.art-4675a69ab8d04accad1a454f5625bff6 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-04-13T13:18:18Z |
| publishDate | 2017-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-4675a69ab8d04accad1a454f5625bff62022-12-22T02:45:23ZengBMCRadiation Oncology1748-717X2017-06-011211710.1186/s13014-017-0843-7Seroma change during magnetic resonance imaging-guided partial breast irradiation and its clinical implicationsSeung Hyuck Jeon0Kyung Hwan Shin1So-Yeon Park2Jung-in Kim3Jong Min Park4Jin Ho Kim5Eui Kyu Chie6Hong-Gyun Wu7Department of Radiation Oncology, Seoul National University College of MedicineDepartment of Radiation Oncology, Seoul National University College of MedicineDepartment of Radiation Oncology, Seoul National University HospitalDepartment of Radiation Oncology, Seoul National University HospitalDepartment of Radiation Oncology, Seoul National University HospitalDepartment of Radiation Oncology, Seoul National University College of MedicineDepartment of Radiation Oncology, Seoul National University College of MedicineDepartment of Radiation Oncology, Seoul National University College of MedicineAbstract Background To investigate the patterns of post-lumpectomy seroma volume (SV) change and related clinical factors to determine the benefits of adaptive planning in magnetic resonance imaging (MRI)-guided partial breast irradiation (PBI). Methods MRI data obtained from 37 women with early breast cancer acquired at simulation and at the 1st, 6th, and 10th fractions were analyzed. The planning target volume (PTV) was defined as unequal margins of 10–15 mm added according to the directional surgical margin status of each seroma. Treatment was performed using a 0.35 T MRI-guided radiotherapy system. Univariate analysis was performed to assess the correlations between SV change rate and clinical factors. Seroma and PTV for adaptive planning were based on the images obtained at the 6th fraction. Results The average time intervals between surgery-simulation, simulation-1st, 1st-6th, and 6th-10th fractions were 23.1, 8.5, 7.2, and 5.9 days, respectively. Of the 37 patients, 33 exhibited decreased SV over the treatment period. The mean SV of these 33 patients decreased from 100% at simulation to 60, 48, and 40% at each MRI scan. In most cases (26/33), the logarithm of SV was inversely proportional to the elapsed time from surgery (R 2 > 0.90, Pearson’s correlation test). The volume of spared normal tissue from adaptive radiotherapy was proportional to the absolute change in SV (R 2 = 0.89, Pearson’s correlation test). Conclusion Seromas exhibit exponential shrinkage over the course of PBI. In patients receiving PBI, frequent monitoring of SV could be helpful in decision-making regarding adaptive planning, especially those with a large seroma.http://link.springer.com/article/10.1186/s13014-017-0843-7Breast cancerPartial breast irradiationAdaptive radiotherapySeroma |
| spellingShingle | Seung Hyuck Jeon Kyung Hwan Shin So-Yeon Park Jung-in Kim Jong Min Park Jin Ho Kim Eui Kyu Chie Hong-Gyun Wu Seroma change during magnetic resonance imaging-guided partial breast irradiation and its clinical implications Radiation Oncology Breast cancer Partial breast irradiation Adaptive radiotherapy Seroma |
| title | Seroma change during magnetic resonance imaging-guided partial breast irradiation and its clinical implications |
| title_full | Seroma change during magnetic resonance imaging-guided partial breast irradiation and its clinical implications |
| title_fullStr | Seroma change during magnetic resonance imaging-guided partial breast irradiation and its clinical implications |
| title_full_unstemmed | Seroma change during magnetic resonance imaging-guided partial breast irradiation and its clinical implications |
| title_short | Seroma change during magnetic resonance imaging-guided partial breast irradiation and its clinical implications |
| title_sort | seroma change during magnetic resonance imaging guided partial breast irradiation and its clinical implications |
| topic | Breast cancer Partial breast irradiation Adaptive radiotherapy Seroma |
| url | http://link.springer.com/article/10.1186/s13014-017-0843-7 |
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