Cellular and molecular studies of the effects of a selective COX-2 inhibitor celecoxib in the cardiac cell line H9c2 and their correlation with death mechanisms

Cellular and molecular studies of the effects of a selective COX-2 inhibitor celecoxib in the cardiac cell line H9c2 and their correlation with death mechanisms

Cardiovascular disease is one of the leading causes of death worldwide, and evidence indicates a correlation between the inflammatory process and cardiac dysfunction. Selective inhibitors of cyclooxygenase-2 (COX-2) enzyme are not recommended for long-term use because of potentially severe side effe...

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Bibliographic Details
Main Authors: K.K. Sakane, C.J. Monteiro, W. Silva, A.R. Silva, P.M. Santos, K.F. Lima, K.C.M. Moraes
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2014-01-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Cellular and molecular analyses
Cell death
Cyclooxygenase-2 inhibitor
H9c2 cardiac cell line
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2014000100050&lng=en&tlng=en

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