Clinicopathological Features and Prognostic Factors in Patients with Small Bowel Adenocarcinoma
Objective:Small bowel adenocarcinoma is a rare tumor, and data on prognosis are limited. We aimed to evaluate the clinicopathological features and prognostic factors in small bowel adenocarcinoma in this study.Method:Twenty-two patients were evaluated. Clinicopathological features and treatment appr...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2022-06-01
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| Series: | Bagcilar Medical Bulletin |
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| Online Access: |
http://behmedicalbulletin.org/archives/archive-detail/article-preview/clinicopathological-features-and-prognostic-factor/52128
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| _version_ | 1797920788969422848 |
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| author | İzzet Doğan Didem Taştekin |
| author_facet | İzzet Doğan Didem Taştekin |
| author_sort | İzzet Doğan |
| collection | DOAJ |
| description | Objective:Small bowel adenocarcinoma is a rare tumor, and data on prognosis are limited. We aimed to evaluate the clinicopathological features and prognostic factors in small bowel adenocarcinoma in this study.Method:Twenty-two patients were evaluated. Clinicopathological features and treatment approaches were retrospectively recorded. The Kaplan-Meier and Cox regression analyses were used to assess overall survival and prognostic factors.Results:The origin sites of the tumor were the duodenum (50%), jejunum (31.8%), and ileum (18.2%), respectively. The number of de novo metastatic patients was 11 (50%). The most common metastatic sites were the peritoneum (%45), liver (%41), and lymph nodes (18%). The median overall survival was 19.9 months (7.3-32.5). One- and two-year survival ratios were 65.9% and 39%, respectively. The response ratio (complete or partial) of first-line chemotherapy in metastatic patients was determined as 46.2%. In multivariate analysis, surgery (p=0.024) and age at diagnosis (p=0.017) were statistically significant prognostic factors for overall survival. However, the site of the tumor (p=0.106), de novo metastatic disease (p=0.323), and the number of metastatic sites (p=0.086) were not.Conclusion:Patients with small bowel adenocarcinoma were diagnosed in advanced stages, and the prognosis of the disease was poor. We observed that removing the primary tumor improved survival, and being older than 60 years was a negative prognostic factor. |
| first_indexed | 2024-04-10T14:07:37Z |
| format | Article |
| id | doaj.art-4676a1b23bcb45529ab64a49dc745afc |
| institution | Directory Open Access Journal |
| issn | 2547-9431 |
| language | English |
| last_indexed | 2024-04-10T14:07:37Z |
| publishDate | 2022-06-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Bagcilar Medical Bulletin |
| spelling | doaj.art-4676a1b23bcb45529ab64a49dc745afc2023-02-15T16:09:55ZengGalenos YayineviBagcilar Medical Bulletin2547-94312022-06-017214414910.4274/BMB.galenos.2022.2022-02-01513049054Clinicopathological Features and Prognostic Factors in Patients with Small Bowel Adenocarcinomaİzzet Doğan0Didem Taştekin1 İstanbul University, İstanbul Faculty of Medicine, Department of Medical Oncology, İstanbul, Turkey İstanbul University, İstanbul Faculty of Medicine, Department of Medical Oncology, İstanbul, Turkey Objective:Small bowel adenocarcinoma is a rare tumor, and data on prognosis are limited. We aimed to evaluate the clinicopathological features and prognostic factors in small bowel adenocarcinoma in this study.Method:Twenty-two patients were evaluated. Clinicopathological features and treatment approaches were retrospectively recorded. The Kaplan-Meier and Cox regression analyses were used to assess overall survival and prognostic factors.Results:The origin sites of the tumor were the duodenum (50%), jejunum (31.8%), and ileum (18.2%), respectively. The number of de novo metastatic patients was 11 (50%). The most common metastatic sites were the peritoneum (%45), liver (%41), and lymph nodes (18%). The median overall survival was 19.9 months (7.3-32.5). One- and two-year survival ratios were 65.9% and 39%, respectively. The response ratio (complete or partial) of first-line chemotherapy in metastatic patients was determined as 46.2%. In multivariate analysis, surgery (p=0.024) and age at diagnosis (p=0.017) were statistically significant prognostic factors for overall survival. However, the site of the tumor (p=0.106), de novo metastatic disease (p=0.323), and the number of metastatic sites (p=0.086) were not.Conclusion:Patients with small bowel adenocarcinoma were diagnosed in advanced stages, and the prognosis of the disease was poor. We observed that removing the primary tumor improved survival, and being older than 60 years was a negative prognostic factor. http://behmedicalbulletin.org/archives/archive-detail/article-preview/clinicopathological-features-and-prognostic-factor/52128 chemotherapyprognosissmall bowel adenocarcinoma |
| spellingShingle | İzzet Doğan Didem Taştekin Clinicopathological Features and Prognostic Factors in Patients with Small Bowel Adenocarcinoma Bagcilar Medical Bulletin chemotherapy prognosis small bowel adenocarcinoma |
| title | Clinicopathological Features and Prognostic Factors in Patients with Small Bowel Adenocarcinoma |
| title_full | Clinicopathological Features and Prognostic Factors in Patients with Small Bowel Adenocarcinoma |
| title_fullStr | Clinicopathological Features and Prognostic Factors in Patients with Small Bowel Adenocarcinoma |
| title_full_unstemmed | Clinicopathological Features and Prognostic Factors in Patients with Small Bowel Adenocarcinoma |
| title_short | Clinicopathological Features and Prognostic Factors in Patients with Small Bowel Adenocarcinoma |
| title_sort | clinicopathological features and prognostic factors in patients with small bowel adenocarcinoma |
| topic | chemotherapy prognosis small bowel adenocarcinoma |
| url |
http://behmedicalbulletin.org/archives/archive-detail/article-preview/clinicopathological-features-and-prognostic-factor/52128
|
| work_keys_str_mv | AT izzetdogan clinicopathologicalfeaturesandprognosticfactorsinpatientswithsmallboweladenocarcinoma AT didemtastekin clinicopathologicalfeaturesandprognosticfactorsinpatientswithsmallboweladenocarcinoma |