Regulation of Kinase Signaling Pathways by α6β4-Integrins and Plectin in Prostate Cancer
Hemidesmosomes (HDs) are adhesive structures that ensure stable anchorage of cells to the basement membrane. They are formed by α6β4-integrin heterodimers and linked to intermediate filaments via plectin. It has been reported that one of the most common events during the pathogenesis of prostate can...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-12-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/1/149 |
| _version_ | 1797626172678340608 |
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| author | Saara Koivusalo Anette Schmidt Aki Manninen Tomasz Wenta |
| author_facet | Saara Koivusalo Anette Schmidt Aki Manninen Tomasz Wenta |
| author_sort | Saara Koivusalo |
| collection | DOAJ |
| description | Hemidesmosomes (HDs) are adhesive structures that ensure stable anchorage of cells to the basement membrane. They are formed by α6β4-integrin heterodimers and linked to intermediate filaments via plectin. It has been reported that one of the most common events during the pathogenesis of prostate cancer (PCa) is the loss of HD organization. While the expression levels of β4-integrins are strongly reduced, the expression levels of α6-integrins and plectin are maintained or even elevated, and seem to promote tumorigenic properties of PCa cells, such as proliferation, invasion, metastasis, apoptosis- and drug-resistance. In this review, we discuss the potential mechanisms of how HD components might contribute to various cellular signaling pathways to promote prostate carcinogenesis. Moreover, we summarize the current knowledge on the involvement of α6β4-integrins and plectin in PCa initiation and progression. |
| first_indexed | 2024-03-11T10:06:43Z |
| format | Article |
| id | doaj.art-467730ae83b942d08774aa34008481bd |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T10:06:43Z |
| publishDate | 2022-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-467730ae83b942d08774aa34008481bd2023-11-16T15:02:18ZengMDPI AGCancers2072-66942022-12-0115114910.3390/cancers15010149Regulation of Kinase Signaling Pathways by α6β4-Integrins and Plectin in Prostate CancerSaara Koivusalo0Anette Schmidt1Aki Manninen2Tomasz Wenta3Disease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, 90220 Oulu, FinlandDisease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, 90220 Oulu, FinlandDisease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, 90220 Oulu, FinlandDisease Networks Research Unit, Faculty of Biochemistry and Molecular Medicine, Biocenter Oulu, University of Oulu, 90220 Oulu, FinlandHemidesmosomes (HDs) are adhesive structures that ensure stable anchorage of cells to the basement membrane. They are formed by α6β4-integrin heterodimers and linked to intermediate filaments via plectin. It has been reported that one of the most common events during the pathogenesis of prostate cancer (PCa) is the loss of HD organization. While the expression levels of β4-integrins are strongly reduced, the expression levels of α6-integrins and plectin are maintained or even elevated, and seem to promote tumorigenic properties of PCa cells, such as proliferation, invasion, metastasis, apoptosis- and drug-resistance. In this review, we discuss the potential mechanisms of how HD components might contribute to various cellular signaling pathways to promote prostate carcinogenesis. Moreover, we summarize the current knowledge on the involvement of α6β4-integrins and plectin in PCa initiation and progression.https://www.mdpi.com/2072-6694/15/1/149α6β4-integrin<i>ITGA6</i><i>ITGB4</i>plectinhemidesmosomesprostate cancer |
| spellingShingle | Saara Koivusalo Anette Schmidt Aki Manninen Tomasz Wenta Regulation of Kinase Signaling Pathways by α6β4-Integrins and Plectin in Prostate Cancer Cancers α6β4-integrin <i>ITGA6</i> <i>ITGB4</i> plectin hemidesmosomes prostate cancer |
| title | Regulation of Kinase Signaling Pathways by α6β4-Integrins and Plectin in Prostate Cancer |
| title_full | Regulation of Kinase Signaling Pathways by α6β4-Integrins and Plectin in Prostate Cancer |
| title_fullStr | Regulation of Kinase Signaling Pathways by α6β4-Integrins and Plectin in Prostate Cancer |
| title_full_unstemmed | Regulation of Kinase Signaling Pathways by α6β4-Integrins and Plectin in Prostate Cancer |
| title_short | Regulation of Kinase Signaling Pathways by α6β4-Integrins and Plectin in Prostate Cancer |
| title_sort | regulation of kinase signaling pathways by α6β4 integrins and plectin in prostate cancer |
| topic | α6β4-integrin <i>ITGA6</i> <i>ITGB4</i> plectin hemidesmosomes prostate cancer |
| url | https://www.mdpi.com/2072-6694/15/1/149 |
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