Sleep disturbance and memory dysfunction in early multiple sclerosis
Abstract Objective Sleep‐dependent memory processing occurs in animals including humans, and disturbed sleep negatively affects memory. Sleep disturbance and memory dysfunction are common in multiple sclerosis (MS), but little is known about the contributions of sleep disturbance to memory in MS. We...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-06-01
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| Series: | Annals of Clinical and Translational Neurology |
| Online Access: | https://doi.org/10.1002/acn3.51262 |
| _version_ | 1818600928705511424 |
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| author | James F. Sumowski Sam Horng Rachel Brandstadter Stephen Krieger Victoria M. Leavitt Ilana Katz Sand Michelle Fabian Sylvia Klineova Robin Graney Claire S. Riley Fred D. Lublin Aaron E. Miller Andrew W. Varga |
| author_facet | James F. Sumowski Sam Horng Rachel Brandstadter Stephen Krieger Victoria M. Leavitt Ilana Katz Sand Michelle Fabian Sylvia Klineova Robin Graney Claire S. Riley Fred D. Lublin Aaron E. Miller Andrew W. Varga |
| author_sort | James F. Sumowski |
| collection | DOAJ |
| description | Abstract Objective Sleep‐dependent memory processing occurs in animals including humans, and disturbed sleep negatively affects memory. Sleep disturbance and memory dysfunction are common in multiple sclerosis (MS), but little is known about the contributions of sleep disturbance to memory in MS. We investigated whether subjective sleep disturbance is linked to worse memory in early MS independently of potential confounders. Methods Persons with early MS (n = 185; ≤5.0 years diagnosed) and demographically matched healthy controls (n = 50) completed four memory tests to derive a memory composite, and four speeded tests to derive a cognitive efficiency composite. Z‐scores were calculated relative to healthy controls. Sleep disturbance was defined by the Insomnia Severity Index score ≥ 10. ANCOVAs examined differences in memory and cognitive efficiency between patients with and without sleep disturbance controlling for potential confounds (e.g., mood, fatigue, disability, T2 lesion volume, gray matter volume). Comparisons were made to healthy controls. Results Seventy‐four (40%) patients reported sleep disturbance. Controlling for all covariates, patients with sleep disturbance had worse memory (z = −0.617; 95% CI: −0.886, −0.348) than patients without disturbance (z = −0.171, −0.425, 0.082, P = .003). Cognitive efficiency did not differ between groups. Relative to healthy controls, memory was worse among patients with sleep disturbance, but not among patients without sleep disturbance. Interpretation Sleep disturbance contributes to MS memory dysfunction, which may help explain differential risk for memory dysfunction in persons with MS, especially since sleep disturbance is common in MS. Potential mechanisms linking sleep disturbance and memory are discussed, as well as recommendations for further mechanistic and interventional research. |
| first_indexed | 2024-12-16T12:43:17Z |
| format | Article |
| id | doaj.art-4678af593570441c83430984cd6a690d |
| institution | Directory Open Access Journal |
| issn | 2328-9503 |
| language | English |
| last_indexed | 2024-12-16T12:43:17Z |
| publishDate | 2021-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Annals of Clinical and Translational Neurology |
| spelling | doaj.art-4678af593570441c83430984cd6a690d2022-12-21T22:31:21ZengWileyAnnals of Clinical and Translational Neurology2328-95032021-06-01861172118210.1002/acn3.51262Sleep disturbance and memory dysfunction in early multiple sclerosisJames F. Sumowski0Sam Horng1Rachel Brandstadter2Stephen Krieger3Victoria M. Leavitt4Ilana Katz Sand5Michelle Fabian6Sylvia Klineova7Robin Graney8Claire S. Riley9Fred D. Lublin10Aaron E. Miller11Andrew W. Varga12Department of Neurology Icahn School of Medicine at Mount Sinai New York New YorkUSADepartment of Neurology Icahn School of Medicine at Mount Sinai New York New YorkUSADepartment of Neurology University of Pennsylvania Philadelphia PennsylvaniaUSADepartment of Neurology Icahn School of Medicine at Mount Sinai New York New YorkUSADepartment of Neurology Columbia University Medical Center New York New YorkUSADepartment of Neurology Icahn School of Medicine at Mount Sinai New York New YorkUSADepartment of Neurology Icahn School of Medicine at Mount Sinai New York New YorkUSADepartment of Neurology Icahn School of Medicine at Mount Sinai New York New YorkUSADepartment of Neurology Icahn School of Medicine at Mount Sinai New York New YorkUSADepartment of Neurology Columbia University Medical Center New York New YorkUSADepartment of Neurology Icahn School of Medicine at Mount Sinai New York New YorkUSADepartment of Neurology Icahn School of Medicine at Mount Sinai New York New YorkUSAIcahn School of Medicine at Mount SinaiDivision of PulmonaryCritical Care and Sleep Medicine New York New YorkUSAAbstract Objective Sleep‐dependent memory processing occurs in animals including humans, and disturbed sleep negatively affects memory. Sleep disturbance and memory dysfunction are common in multiple sclerosis (MS), but little is known about the contributions of sleep disturbance to memory in MS. We investigated whether subjective sleep disturbance is linked to worse memory in early MS independently of potential confounders. Methods Persons with early MS (n = 185; ≤5.0 years diagnosed) and demographically matched healthy controls (n = 50) completed four memory tests to derive a memory composite, and four speeded tests to derive a cognitive efficiency composite. Z‐scores were calculated relative to healthy controls. Sleep disturbance was defined by the Insomnia Severity Index score ≥ 10. ANCOVAs examined differences in memory and cognitive efficiency between patients with and without sleep disturbance controlling for potential confounds (e.g., mood, fatigue, disability, T2 lesion volume, gray matter volume). Comparisons were made to healthy controls. Results Seventy‐four (40%) patients reported sleep disturbance. Controlling for all covariates, patients with sleep disturbance had worse memory (z = −0.617; 95% CI: −0.886, −0.348) than patients without disturbance (z = −0.171, −0.425, 0.082, P = .003). Cognitive efficiency did not differ between groups. Relative to healthy controls, memory was worse among patients with sleep disturbance, but not among patients without sleep disturbance. Interpretation Sleep disturbance contributes to MS memory dysfunction, which may help explain differential risk for memory dysfunction in persons with MS, especially since sleep disturbance is common in MS. Potential mechanisms linking sleep disturbance and memory are discussed, as well as recommendations for further mechanistic and interventional research.https://doi.org/10.1002/acn3.51262 |
| spellingShingle | James F. Sumowski Sam Horng Rachel Brandstadter Stephen Krieger Victoria M. Leavitt Ilana Katz Sand Michelle Fabian Sylvia Klineova Robin Graney Claire S. Riley Fred D. Lublin Aaron E. Miller Andrew W. Varga Sleep disturbance and memory dysfunction in early multiple sclerosis Annals of Clinical and Translational Neurology |
| title | Sleep disturbance and memory dysfunction in early multiple sclerosis |
| title_full | Sleep disturbance and memory dysfunction in early multiple sclerosis |
| title_fullStr | Sleep disturbance and memory dysfunction in early multiple sclerosis |
| title_full_unstemmed | Sleep disturbance and memory dysfunction in early multiple sclerosis |
| title_short | Sleep disturbance and memory dysfunction in early multiple sclerosis |
| title_sort | sleep disturbance and memory dysfunction in early multiple sclerosis |
| url | https://doi.org/10.1002/acn3.51262 |
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