Better Pandemic Influenza Preparedness through Adjuvant Technology Transfer: Challenges and Lessons Learned
Adequate global vaccine coverage during an influenza pandemic is essential to mitigate morbidity, mortality, and economic impact. Vaccine development and production needs to be sufficient to meet a vast global demand, requiring international cooperation and local vaccine production capacity, especia...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Vaccines |
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| Online Access: | https://www.mdpi.com/2076-393X/9/5/461 |
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| author | Céline H. Lemoine Reviany V. Nidom Roland Ventura Setyarina Indrasari Irine Normalina Kuncoro Puguh Santoso Francis Derouet Christophe Barnier-Quer Gerrit Borchard Nicolas Collin Chairul A. Nidom |
| author_facet | Céline H. Lemoine Reviany V. Nidom Roland Ventura Setyarina Indrasari Irine Normalina Kuncoro Puguh Santoso Francis Derouet Christophe Barnier-Quer Gerrit Borchard Nicolas Collin Chairul A. Nidom |
| author_sort | Céline H. Lemoine |
| collection | DOAJ |
| description | Adequate global vaccine coverage during an influenza pandemic is essential to mitigate morbidity, mortality, and economic impact. Vaccine development and production needs to be sufficient to meet a vast global demand, requiring international cooperation and local vaccine production capacity, especially in resource-constrained countries. The use of adjuvants is one approach to augment the number of available vaccine doses and to overcome potential vaccine shortages. Appropriately selected adjuvant technologies can decrease the amount of vaccine antigen required per dose, may broaden or lengthen the conferred protection against disease, and may even allow protective single-dose vaccination. Here we describe a technology transfer collaboration between Switzerland and Indonesia that led to the establishment of a vaccine formulation platform in Surabaya which involved the transfer of equipment and expertise to enable research and development of adjuvanted vaccine formulations and delivery systems. This new Indonesian capability aims to facilitate local and regional access to know-how relating to adjuvanted vaccine formulations, thus promoting their application to local vaccine developers. In this review, we aim to share the “lessons learned” from this project to both support and inspire future scientific collaborations of a similar nature. |
| first_indexed | 2024-03-10T11:41:18Z |
| format | Article |
| id | doaj.art-4678c2cda4f04cd7b13cd7acaf0afdb1 |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T11:41:18Z |
| publishDate | 2021-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-4678c2cda4f04cd7b13cd7acaf0afdb12023-11-21T18:28:01ZengMDPI AGVaccines2076-393X2021-05-019546110.3390/vaccines9050461Better Pandemic Influenza Preparedness through Adjuvant Technology Transfer: Challenges and Lessons LearnedCéline H. Lemoine0Reviany V. Nidom1Roland Ventura2Setyarina Indrasari3Irine Normalina4Kuncoro Puguh Santoso5Francis Derouet6Christophe Barnier-Quer7Gerrit Borchard8Nicolas Collin9Chairul A. Nidom10Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Rue Michel-Servet 1, 1221 Geneva, SwitzerlandProfessor Nidom Foundation, Surabaya 60298, IndonesiaVaccine Formulation Institute, Chemin des Aulx 14, 1228 Plan-les-Ouates, SwitzerlandProfessor Nidom Foundation, Surabaya 60298, IndonesiaProfessor Nidom Foundation, Surabaya 60298, IndonesiaProfessor Nidom Foundation, Surabaya 60298, IndonesiaCentre Laboratoire d’Epalinges (CLE), University of Lausanne, Ch. des Boveresses 155, 1011 Epalinges, SwitzerlandVaccine Formulation Laboratory, University of Lausanne, Ch. des Boveresses 155, 1066 Epalinges, SwitzerlandInstitute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, Rue Michel-Servet 1, 1221 Geneva, SwitzerlandVaccine Formulation Institute, Chemin des Aulx 14, 1228 Plan-les-Ouates, SwitzerlandProfessor Nidom Foundation, Surabaya 60298, IndonesiaAdequate global vaccine coverage during an influenza pandemic is essential to mitigate morbidity, mortality, and economic impact. Vaccine development and production needs to be sufficient to meet a vast global demand, requiring international cooperation and local vaccine production capacity, especially in resource-constrained countries. The use of adjuvants is one approach to augment the number of available vaccine doses and to overcome potential vaccine shortages. Appropriately selected adjuvant technologies can decrease the amount of vaccine antigen required per dose, may broaden or lengthen the conferred protection against disease, and may even allow protective single-dose vaccination. Here we describe a technology transfer collaboration between Switzerland and Indonesia that led to the establishment of a vaccine formulation platform in Surabaya which involved the transfer of equipment and expertise to enable research and development of adjuvanted vaccine formulations and delivery systems. This new Indonesian capability aims to facilitate local and regional access to know-how relating to adjuvanted vaccine formulations, thus promoting their application to local vaccine developers. In this review, we aim to share the “lessons learned” from this project to both support and inspire future scientific collaborations of a similar nature.https://www.mdpi.com/2076-393X/9/5/461pandemic preparednesstechnology transferadjuvanted vaccinesinfluenzalessons learnedglobal health |
| spellingShingle | Céline H. Lemoine Reviany V. Nidom Roland Ventura Setyarina Indrasari Irine Normalina Kuncoro Puguh Santoso Francis Derouet Christophe Barnier-Quer Gerrit Borchard Nicolas Collin Chairul A. Nidom Better Pandemic Influenza Preparedness through Adjuvant Technology Transfer: Challenges and Lessons Learned Vaccines pandemic preparedness technology transfer adjuvanted vaccines influenza lessons learned global health |
| title | Better Pandemic Influenza Preparedness through Adjuvant Technology Transfer: Challenges and Lessons Learned |
| title_full | Better Pandemic Influenza Preparedness through Adjuvant Technology Transfer: Challenges and Lessons Learned |
| title_fullStr | Better Pandemic Influenza Preparedness through Adjuvant Technology Transfer: Challenges and Lessons Learned |
| title_full_unstemmed | Better Pandemic Influenza Preparedness through Adjuvant Technology Transfer: Challenges and Lessons Learned |
| title_short | Better Pandemic Influenza Preparedness through Adjuvant Technology Transfer: Challenges and Lessons Learned |
| title_sort | better pandemic influenza preparedness through adjuvant technology transfer challenges and lessons learned |
| topic | pandemic preparedness technology transfer adjuvanted vaccines influenza lessons learned global health |
| url | https://www.mdpi.com/2076-393X/9/5/461 |
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