A first case report of clinical response to targeted therapy in a patient with primary myoepithelial carcinoma of the lung harboring EGFR exon 19 deletion
Abstract Background Primary myoepithelial carcinoma of the lung is a rare subtype in lung cancer. Comprehensive molecular profiling of myoepithelial carcinoma of the lung is absent, neither was clinical evidence of targeted therapy available for this disease. Therefore, the optimal treatment regimen...
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| Format: | Article |
| Language: | English |
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BMC
2020-06-01
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| Series: | Diagnostic Pathology |
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| Online Access: | http://link.springer.com/article/10.1186/s13000-020-00986-0 |
| _version_ | 1819203018609917952 |
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| author | Xiaohong Xie Xinqing Lin Ming Liu Yinyin Qin Ming Ouyang Shiyue Li Yingying Gu Shuyin Chen Jianxing Xiang Chengzhi Zhou |
| author_facet | Xiaohong Xie Xinqing Lin Ming Liu Yinyin Qin Ming Ouyang Shiyue Li Yingying Gu Shuyin Chen Jianxing Xiang Chengzhi Zhou |
| author_sort | Xiaohong Xie |
| collection | DOAJ |
| description | Abstract Background Primary myoepithelial carcinoma of the lung is a rare subtype in lung cancer. Comprehensive molecular profiling of myoepithelial carcinoma of the lung is absent, neither was clinical evidence of targeted therapy available for this disease. Therefore, the optimal treatment regimen of this tumor needs to be established. Case presentation Here we present a case of a 68-year-old patient with stage IVB primary myoepithelial carcinoma of the lung who harbored EGFR exon 19 deletion and KRAS mutation and underwent icotinib targeted therapy, achieving partial response (PR) with progression free survival (PFS) of 3 months. Conclusion To our knowledge, this study describes the first documented case of primary myoepithelial carcinoma lung cancer patient harboring EGFR exon 19 deletion and KRAS mutation, and showed clinical efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) treatment in this patient. |
| first_indexed | 2024-12-23T04:13:15Z |
| format | Article |
| id | doaj.art-46791870659346f4bf65f9a669004650 |
| institution | Directory Open Access Journal |
| issn | 1746-1596 |
| language | English |
| last_indexed | 2024-12-23T04:13:15Z |
| publishDate | 2020-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Diagnostic Pathology |
| spelling | doaj.art-46791870659346f4bf65f9a6690046502022-12-21T18:00:25ZengBMCDiagnostic Pathology1746-15962020-06-011511610.1186/s13000-020-00986-0A first case report of clinical response to targeted therapy in a patient with primary myoepithelial carcinoma of the lung harboring EGFR exon 19 deletionXiaohong Xie0Xinqing Lin1Ming Liu2Yinyin Qin3Ming Ouyang4Shiyue Li5Yingying Gu6Shuyin Chen7Jianxing Xiang8Chengzhi Zhou9Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory DiseaseDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory DiseaseDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory DiseaseDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory DiseaseDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory DiseaseDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory DiseaseDepartment of Respiratory Pathology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory DiseaseBurning Rock BiotechBurning Rock BiotechDepartment of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory DiseaseAbstract Background Primary myoepithelial carcinoma of the lung is a rare subtype in lung cancer. Comprehensive molecular profiling of myoepithelial carcinoma of the lung is absent, neither was clinical evidence of targeted therapy available for this disease. Therefore, the optimal treatment regimen of this tumor needs to be established. Case presentation Here we present a case of a 68-year-old patient with stage IVB primary myoepithelial carcinoma of the lung who harbored EGFR exon 19 deletion and KRAS mutation and underwent icotinib targeted therapy, achieving partial response (PR) with progression free survival (PFS) of 3 months. Conclusion To our knowledge, this study describes the first documented case of primary myoepithelial carcinoma lung cancer patient harboring EGFR exon 19 deletion and KRAS mutation, and showed clinical efficacy of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKI) treatment in this patient.http://link.springer.com/article/10.1186/s13000-020-00986-0LungMyoepithelial carcinomaSalivary gland type tumorEGFR 19delIcotinib |
| spellingShingle | Xiaohong Xie Xinqing Lin Ming Liu Yinyin Qin Ming Ouyang Shiyue Li Yingying Gu Shuyin Chen Jianxing Xiang Chengzhi Zhou A first case report of clinical response to targeted therapy in a patient with primary myoepithelial carcinoma of the lung harboring EGFR exon 19 deletion Diagnostic Pathology Lung Myoepithelial carcinoma Salivary gland type tumor EGFR 19del Icotinib |
| title | A first case report of clinical response to targeted therapy in a patient with primary myoepithelial carcinoma of the lung harboring EGFR exon 19 deletion |
| title_full | A first case report of clinical response to targeted therapy in a patient with primary myoepithelial carcinoma of the lung harboring EGFR exon 19 deletion |
| title_fullStr | A first case report of clinical response to targeted therapy in a patient with primary myoepithelial carcinoma of the lung harboring EGFR exon 19 deletion |
| title_full_unstemmed | A first case report of clinical response to targeted therapy in a patient with primary myoepithelial carcinoma of the lung harboring EGFR exon 19 deletion |
| title_short | A first case report of clinical response to targeted therapy in a patient with primary myoepithelial carcinoma of the lung harboring EGFR exon 19 deletion |
| title_sort | first case report of clinical response to targeted therapy in a patient with primary myoepithelial carcinoma of the lung harboring egfr exon 19 deletion |
| topic | Lung Myoepithelial carcinoma Salivary gland type tumor EGFR 19del Icotinib |
| url | http://link.springer.com/article/10.1186/s13000-020-00986-0 |
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