Quantitative Proteomic Profiling Identifies SOX8 as Novel Regulator of Drug Resistance in Gestational Trophoblastic Neoplasia

Quantitative Proteomic Profiling Identifies SOX8 as Novel Regulator of Drug Resistance in Gestational Trophoblastic Neoplasia

The development of drug resistance remains one of the major challenges to current chemotherapeutic regimens in gestational trophoblastic neoplasia (GTN). Further understanding on the mechanisms of drug resistance would help to develop more effective therapy to treat GTN. Herein, tandem mass tag-base...

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Bibliographic Details
Main Authors: Fu Jun, Zheng Peng, Yi Zhang, Dazun Shi
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Oncology
Subjects:
gestational trophoblastic neoplasia
drug resistance
quantitative proteomics
SOX8
reactive oxygen species
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00557/full

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