Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau
Lack of disease-modifying therapy against epileptogenesis reflects the complexity of the disease pathogenesis as well as the high demand to explore novel treatment strategies. In the pursuit of developing new therapeutic strategies against epileptogenesis, neurodegenerative proteins have recently ga...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/9/6/122 |
| _version_ | 1797565488947003392 |
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| author | Yam Nath Paudel Efthalia Angelopoulou Christina Piperi Iekhsan Othman Mohd. Farooq Shaikh |
| author_facet | Yam Nath Paudel Efthalia Angelopoulou Christina Piperi Iekhsan Othman Mohd. Farooq Shaikh |
| author_sort | Yam Nath Paudel |
| collection | DOAJ |
| description | Lack of disease-modifying therapy against epileptogenesis reflects the complexity of the disease pathogenesis as well as the high demand to explore novel treatment strategies. In the pursuit of developing new therapeutic strategies against epileptogenesis, neurodegenerative proteins have recently gained increased attention. Owing to the fact that neurodegenerative disease and epileptogenesis possibly share a common underlying mechanism, targeting neurodegenerative proteins against epileptogenesis might represent a promising therapeutic approach. Herein, we review the association of neurodegenerative proteins, such as α-synuclein, amyloid-beta (Aβ), and tau protein, with epilepsy. Providing insight into the α-synuclein, Aβ and tau protein-mediated neurodegeneration mechanisms, and their implication in epileptogenesis will pave the way towards the development of new agents and treatment strategies. |
| first_indexed | 2024-03-10T19:12:53Z |
| format | Article |
| id | doaj.art-467e3142a97947889847912080da75d2 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-10T19:12:53Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-467e3142a97947889847912080da75d22023-11-20T03:38:47ZengMDPI AGBiology2079-77372020-06-019612210.3390/biology9060122Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and TauYam Nath Paudel0Efthalia Angelopoulou1Christina Piperi2Iekhsan Othman3Mohd. Farooq Shaikh4Neuropharmacology Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Selangor 47500, MalaysiaDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75 M. Asias Street, 11527 Athens, GreeceDepartment of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 75 M. Asias Street, 11527 Athens, GreeceNeuropharmacology Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Selangor 47500, MalaysiaNeuropharmacology Research Strength, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway, Selangor 47500, MalaysiaLack of disease-modifying therapy against epileptogenesis reflects the complexity of the disease pathogenesis as well as the high demand to explore novel treatment strategies. In the pursuit of developing new therapeutic strategies against epileptogenesis, neurodegenerative proteins have recently gained increased attention. Owing to the fact that neurodegenerative disease and epileptogenesis possibly share a common underlying mechanism, targeting neurodegenerative proteins against epileptogenesis might represent a promising therapeutic approach. Herein, we review the association of neurodegenerative proteins, such as α-synuclein, amyloid-beta (Aβ), and tau protein, with epilepsy. Providing insight into the α-synuclein, Aβ and tau protein-mediated neurodegeneration mechanisms, and their implication in epileptogenesis will pave the way towards the development of new agents and treatment strategies.https://www.mdpi.com/2079-7737/9/6/122neurodegenerationepileptogenesisalpha-synucleinAβtau |
| spellingShingle | Yam Nath Paudel Efthalia Angelopoulou Christina Piperi Iekhsan Othman Mohd. Farooq Shaikh Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau Biology neurodegeneration epileptogenesis alpha-synuclein Aβ tau |
| title | Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau |
| title_full | Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau |
| title_fullStr | Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau |
| title_full_unstemmed | Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau |
| title_short | Revisiting the Impact of Neurodegenerative Proteins in Epilepsy: Focus on Alpha-Synuclein, Beta-Amyloid, and Tau |
| title_sort | revisiting the impact of neurodegenerative proteins in epilepsy focus on alpha synuclein beta amyloid and tau |
| topic | neurodegeneration epileptogenesis alpha-synuclein Aβ tau |
| url | https://www.mdpi.com/2079-7737/9/6/122 |
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